DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and p4ha2

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	524	Identity:	183/524 - (34%)
Similarity:	288/524 - (54%)	Gaps:	48/524 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDK-ARSST---EEYLSNPLN 94
            ||:..|..|:..|.:|:.:|::|....|:||:|||.....|    || .|:||   |.:|::|:|
Zfish    24 TSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKL----DKLTRTSTSDPEGFLAHPVN 84

  Fly    95 SFSLIRRMNRDWI-IWQLYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTYGLKVPE 158
            ::.|::|:|.:|. :..|.:.|| ....:..:...|::.|...|.:.|..||.|:|.||.|....
Zfish    85 AYKLMKRLNTEWSELESLVLQDP-SDGFISNMSVHRQYFPDEEDEKGAAKALLRLQDTYKLDAES 148

  Fly   159 ISHGFL------NGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEIS 217
            .|.|.|      :|.:||..|||.|.:.||::.::..:|..:..|:.||:..|::...|   :..
Zfish   149 FSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSVLWMQQSLRQMDSGEEA---KTP 210

  Fly   218 KNEVRMVYAETLLKLNQHADALKVVNIALTDNP-HD--------IKLLLKKSEIETMIRTGTNNA 273
            |.:|....:.::.::.....|:::....|..:| |.        .:.||.| |::...:|....|
Zfish   211 KADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQRAGGNLRYFERLLSK-ELQDSGQTQPEPA 274

  Fly   274 P--PVKVQATGVP-------TAYQIGCRGQ---FPPSADSKLYCLY---NRTTSPFLILAPLKME 323
            .  |:::.....|       .||:..|||:   ......|:|:|.|   ||  :|.|:|.|:|.|
Zfish   275 DERPIQLDTYQRPKDYLPEREAYEALCRGEGVKMTTKRQSRLFCRYRDGNR--NPRLLLKPMKEE 337

  Fly   324 LVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLT 388
            .....|::|.:.:.||.:||::::.:|||.|.||||....:|...|...|.||.||.....:|:.
Zfish   338 DEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDPKTGVLTVAHYRVSKSAWLEGEDDPVI 402

  Fly   389 VRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSN--MTAMSGDRIATVLFYLTD 451
            .|:|.||.|:||..:..:|:||:.|||:||.|:.|:||..|...:  .:..:|:|:||.|.|::|
Zfish   403 ARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDFSRKDEPDAFKSLGTGNRVATYLNYMSD 467

  Fly   452 VEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIF 516
            ||.|||||||:...:|:|::|:.|.||||..:|:.|.:|.||||||:||||||.||||.||.|.|
Zfish   468 VEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGDYRTRHAACPVLVGSKWVSNKWIHERGQEF 532

  Fly   517 SRPC 520
            .|||
Zfish   533 RRPC 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	43/133 (32%)
		TPR_11	179..250	CDD:290150	12/70 (17%)
		TPR repeat	179..213	CDD:276809	8/33 (24%)
		TPR repeat	218..248	CDD:276809	4/29 (14%)
		P4Hc	339..510	CDD:214780	81/172 (47%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	43/133 (32%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	81/172 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820