DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaPV and P4ha3

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	160/556 - (28%)
Similarity:	253/556 - (45%)	Gaps:	133/556 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLLLLR-------QAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRL 76
            ||:||.       .|.|.|...:::..:.:.|..|.:|:..|..|....|.:|:.:.|..
  Rat    10 LLVLLELGVGDPAAAAGREDTFSALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFY----- 69

  Fly    77 ENDKARSSTEEY---LSNPLNSFSLIRRMNRDW--IIWQLYMDDPV-----GISQVERIQELREH 131
              ||..|..|:.   :.|||.:|:||:|:..||  ::..|...:.:     |..:||      :.
  Rat    70 --DKVLSLHEDLKIPVVNPLLAFTLIKRLQSDWRNVVHSLEATENIRALKDGYEKVE------QD 126

  Fly   132 MPTHTDVEEAVTALDRIQSTYGLKVPEISHGF-----------LNGKQYNVSLTVLDTYAMGQIL 185
            :|...|:|.|..||.|:|..|.|.|..::.|.           |...:...|||..|.:.:|::.
  Rat   127 LPAFEDLEGAARALMRLQDVYMLNVKGLAQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVA 191

  Fly   186 FDQKNYLAAASWIYQSVVLMEAFSMAAPLEISKNEVRMVYAETLLKLNQHA---DALKV------ 241
            :|..:|..|..|:.::|.|.                |..|.|  .|....|   |||..
  Rat   192 YDTGDYYHAIPWLEEAVSLF----------------RRSYGE--WKTEDEASLEDALDYLAFACY 238

  Fly   242 ----VNIALT----------DNPHDIKLLLKKSEI----------ETMIRTGTNNAPPVKVQAT- 281
                |:.||:          ||....:.:||...:          ||.|:  ..|.|.::.:.|
  Rat   239 QVGNVSCALSLSREFLVYSPDNKRMARNVLKYERLLAENGHLMAAETAIQ--RPNVPHLQTRDTY 301

  Fly   282 --------GVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAPLKMELVGLDPYMVLYHDVL 338
                    ..||.|||       ||    |||.|...:||:|:|.|.:.|::.|.|.:.||||.:
  Rat   302 EGLCQTLGSQPTHYQI-------PS----LYCSYETNSSPYLLLQPARKEVIHLRPLVALYHDFV 355

  Fly   339 SPKEIKELQGMATPGLKRATVYQASSGRNEV-VKTRTSKVAWFPDGYNPLTVRLNARISDMTGFN 402
            |.:|.::::.:|.|.|:|:.|   :||..:: |:.|.||.||..|..:|:.|.|:.||:.:||.:
  Rat   356 SDEEAQKIRELAEPWLQRSVV---ASGEKQLQVEYRISKSAWLKDTVDPVLVTLDRRIAALTGLD 417

  Fly   403 LYG--SEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAM-SGDRIATVLFYLTDVEQGGATVF---- 460
            :..  :|.||::|||:||||:.|:|.....:|.:..| ||:|:||::.||:.||.||||.|
  Rat   418 IQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYKMKSGNRVATLMIYLSSVEAGGATAFIYGN 482

  Fly   461 ---PNIRKAVFPQRGSVVMWYNLKDNGQ--IDTQTL 491
               |.::   :|..|...|..|.:|...  :.|:||
  Rat   483 FSVPVVK---WPTSGYTSMDRNSEDPAAPILKTETL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	37/149 (25%)
		TPR_11	179..250	CDD:290150	19/93 (20%)
		TPR repeat	179..213	CDD:276809	7/33 (21%)
		TPR repeat	218..248	CDD:276809	11/52 (21%)
		P4Hc	339..510	CDD:214780	60/166 (36%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	21/80 (26%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	50/124 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750