Protein Alignment PH4alphaPV and P4ha3

DIOPT Version :10

• Sequence 1: NP_733395.1
• Gene: PH4alphaPV / 43640
• FlyBaseID: FBgn0051015
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: XP_063123241.1
• Gene: P4ha3 / 361612
• RGDID: 735150
• Length: 584
• Species: Rattus norvegicus
• Alignment Length: 569
• Identity: 161/569 - (28%)
• Similarity: 255/569 - (44%)
• Gaps: 132/569 - (23%)

  Fly    19 LLLLLR-------QAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRL 76
            ||:||.       .|.|.|...:::..:.:.|..|.:|:..|..|....|.:|:.:.|..
  Rat    10 LLVLLELGVGDPAAAAGREDTFSALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFY----- 69

  Fly    77 ENDKARSSTEEY---LSNPLNSFSLIRRMNRDW--IIWQLYMDDPV-----GISQVERIQELREH 131
              ||..|..|:.   :.|||.:|:||:|:..||  ::..|...:.:     |..:||      :.
  Rat    70 --DKVLSLHEDLKIPVVNPLLAFTLIKRLQSDWRNVVHSLEATENIRALKDGYEKVE------QD 126

  Fly   132 MPTHTDVEEAVTALDRIQSTYGLKVPEISHGF-----------LNGKQYNVSLTVLDTYAMGQIL 185
            :|...|:|.|..||.|:|..|.|.|..::.|.           |...:...|||..|.:.:|::.
  Rat   127 LPAFEDLEGAARALMRLQDVYMLNVKGLAQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVA 191

  Fly   186 FDQKNYLAAASWIYQSVVLMEAFSMAAPLEISKNEVRMVYAETLLKLNQHA---DALKV------ 241
            :|..:|..|..|:.::|.|.                |..|.|  .|....|   |||..
  Rat   192 YDTGDYYHAIPWLEEAVSLF----------------RRSYGE--WKTEDEASLEDALDYLAFACY 238

  Fly   242 ----VNIALT----------DNPHDIKLLLKKSEI----------ETMIRTGTNNAPPVKVQAT- 281
                |:.||:          ||....:.:||...:          ||.|:  ..|.|.::.:.|
  Rat   239 QVGNVSCALSLSREFLVYSPDNKRMARNVLKYERLLAENGHLMAAETAIQ--RPNVPHLQTRDTY 301

  Fly   282 --------GVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAPLKMELVGLDPYMVLYHDVL 338
                    ..||.|||       ||    |||.|...:||:|:|.|.:.|::.|.|.:.||||.:
  Rat   302 EGLCQTLGSQPTHYQI-------PS----LYCSYETNSSPYLLLQPARKEVIHLRPLVALYHDFV 355

  Fly   339 SPKEIKELQGMATPGLKRATVYQASSGRNEV-VKTRTSKVAWFPDGYNPLTVRLNARISDMTGFN 402
            |.:|.::::.:|.|.|:|:.|   :||..:: |:.|.||.||..|..:|:.|.|:.||:.:||.:
  Rat   356 SDEEAQKIRELAEPWLQRSVV---ASGEKQLQVEYRISKSAWLKDTVDPVLVTLDRRIAALTGLD 417

  Fly   403 LYG--SEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAM-SGDRIATVLFYLTDVEQGGAT--VFPN 462
            :..  :|.||::|||:||||:.|:|.....:|.:..| ||:|:||::.||:.||.||||  ::.|
  Rat   418 IQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYKMKSGNRVATLMIYLSSVEAGGATAFIYGN 482

  Fly   463 IRKAVFPQRGSVVMWYNL---KDNGQIDTQTLHAACPVIVGSKWVCNKW 508
            ....|...||.:..:...   .:.|.:...||.|.|      .|..:.|
  Rat   483 FSVPVVKVRGMLHCFGGTCTGVERGMMTHFTLAALC------WWETSGW 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..166	CDD:462433	38/151 (25%)
		NrfG	179..>256	CDD:443378	20/99 (20%)
		TPR repeat	179..213	CDD:276809	7/33 (21%)
		TPR repeat	218..248	CDD:276809	11/52 (21%)
		P4Hc	339..510	CDD:214780	61/179 (34%)
P4ha3	XP_063123241.1	None