Protein Alignment PH4alphaPV and P4ha2

DIOPT Version :10

• Sequence 1: NP_733395.1
• Gene: PH4alphaPV / 43640
• FlyBaseID: FBgn0051015
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001101745.1
• Gene: P4ha2 / 360526
• RGDID: 1309673
• Length: 535
• Species: Rattus norvegicus
• Alignment Length: 536
• Identity: 175/536 - (32%)
• Similarity: 286/536 - (53%)
• Gaps: 42/536 - (7%)

  Fly    17 QVLLLLLR--------QAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITS 73
            |||:||:.        ||:    ..||:..|..|:..|..|:.:|::|.:..|.||..::...:.
  Rat     4 QVLVLLMSWFGVLSWVQAE----FFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASK 64

  Fly    74 LRLENDKARSSTEEYLSNPLNSFSLIRRMNRDW-IIWQLYMDDPVGISQVERIQELREHMPTHTD 137
            :.....|:.:..|.||::|:|::.|::|:|.|| .:..|.:.| .....|..:...|:..||..|
  Rat    65 MEALTSKSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQD-AAAGFVANLSVQRQFFPTDED 128

  Fly   138 VEEAVTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSV 202
            ...|..||.|:|.||.|....||.|.|.|.:|...|:|.|.:.||:..:::.:|.....|:.|.:
  Rat   129 ESGAARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVL 193

  Fly   203 VLMEAFSMAAPLEISKNEVRMVYAETLLKLNQHADALKVVNIALTDNP-HD--------IKLLLK 258
            ..::|...|.   ::|:.|....:..:.:|.....|:::....|:.:| |:        .:.||:
  Rat   194 KQLDAGEEAT---VTKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLE 255

  Fly   259 KSEIETMI-RTGTNNAPPVKVQATGVP-----TAYQIGCRGQ---FPPSADSKLYCLY---NRTT 311
            :...:::. :|....|....:....|.     ..|:..|||:   ..|....:|:|.|   ||.
  Rat   256 EERGKSLSNQTDAGLASQENLYERPVDYLPERDVYESLCRGEGIKMTPRRQKRLFCRYHHGNRV- 319

  Fly   312 SPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSK 376
             |.|::||.|.|.....|::|.|:||:|.:||:.::.:|.|.|.||||....:|...|...|.||
  Rat   320 -PQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSK 383

  Fly   377 VAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDF--FNKTNSNMTAMSG 439
            .:|..:..:|:..|:|.|:..:||..:..:|:||:.|||:||.|:.|:||  .::.::.....:|
  Rat   384 SSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDERDAFKRLGTG 448

  Fly   440 DRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWV 504
            :|:||.|.|::|||.|||||||::..|::|::|:.|.||||..:|:.|.:|.||||||:||.|||
  Rat   449 NRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWV 513

  Fly   505 CNKWIREREQIFSRPC 520
            .|||..||.|.|.|||
  Rat   514 SNKWFHERGQEFLRPC 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..166	CDD:462433	40/131 (31%)
		NrfG	179..>256	CDD:443378	14/85 (16%)
		TPR repeat	179..213	CDD:276809	7/33 (21%)
		TPR repeat	218..248	CDD:276809	5/29 (17%)
		P4Hc	339..510	CDD:214780	75/172 (44%)
P4ha2	NP_001101745.1	P4Ha_N	26..157	CDD:462433	40/131 (31%)
		P4Hc	346..519	CDD:214780	75/172 (44%)