Protein Alignment PH4alphaPV and P4ha3

DIOPT Version :10

• Sequence 1: NP_733395.1
• Gene: PH4alphaPV / 43640
• FlyBaseID: FBgn0051015
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: XP_006508007.1
• Gene: P4ha3 / 320452
• MGIID: 2444049
• Length: 551
• Species: Mus musculus
• Alignment Length: 585
• Identity: 178/585 - (30%)
• Similarity: 274/585 - (46%)
• Gaps: 131/585 - (22%)

  Fly    19 LLLLL------RQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLE 77
            ||.||      ..|.|.|...:::..:.:.|..|.:|:..|..|....|.:|:.:.|..
Mouse     9 LLALLALGGDPAAATGREDTFSALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFY------ 67

  Fly    78 NDKARSSTEEY---LSNPLNSFSLIRRMNRDW--IIWQLYMDDPV-----GISQVERIQELREHM 132
             ||..|..|:.   :.|||.:|:||:|:..||  ::..|...:.:     |..:||      :.:
Mouse    68 -DKVLSLHEDLKIPVVNPLLAFTLIKRLQSDWRNVVHSLEATENIRALKDGYEKVE------QDL 125

  Fly   133 PTHTDVEEAVTALDRIQSTYGLKVPEISHGF-----------LNGKQYNVSLTVLDTYAMG---- 182
            |...|:|.|..||.|:|..|.|.|..::.|.           |...:...|||..|.:.:|
Mouse   126 PAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKPSC 190

  Fly   183 -----QILFDQKNYLAAASWIYQSVVLME---------------------AF------SMAAPLE 215
                 |:.:|..:|..|..|:.::|.|..                     ||      :::..|.
Mouse   191 GSRSLQVAYDTGDYYHAIPWLEEAVSLFRRAHGEWKTEDEASLEDALDYLAFACFQVGNVSCALS 255

  Fly   216 ISKNEVRMVY-------AETLLKLNQHADALKVVNIALTDNPHDIKLLLKKSEIETMIRTGTNNA 273
            :|:.  .:||       |..:||..:          .|.:|.|.:       ..||.|:  ..|.
Mouse   256 LSRE--FLVYSPDNKRMARNVLKYER----------LLAENGHQM-------AAETAIQ--RPNV 299

  Fly   274 PPVKVQAT---------GVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAPLKMELVGLDP 329
            |.::.:.|         ..||.|||       ||    |||.|...:||:|:|.|.:.|:|.|.|
Mouse   300 PHLQTRDTYEGLCQTLGSQPTHYQI-------PS----LYCSYETNSSPYLLLQPARKEVVHLRP 353

  Fly   330 YMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEV-VKTRTSKVAWFPDGYNPLTVRLNA 393
            .:.||||.:|.:|.::::.:|.|.|:|:.|   :||..:: |:.|.||.||..|..:|:.|.|:.
Mouse   354 LIALYHDFVSDEEAQKIRELAEPWLQRSVV---ASGEKQLQVEYRISKSAWLKDTVDPMLVTLDH 415

  Fly   394 RISDMTGFNLYG--SEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAM-SGDRIATVLFYLTDVEQG 455
            ||:.:||.::..  :|.||::|||:||||:.|:|.....:|.:..| ||:|:||.:.||:.||.|
Mouse   416 RIAALTGLDIQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAG 480

  Fly   456 GATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRPC 520
            |||.|.....:|...:.:.:.|:||..:|:.|..||||.|||:||.|||.||||.|..|.|.|||
Mouse   481 GATAFIYGNFSVPVVKNAALFWWNLHRSGEGDGDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPC 545

  Fly   521  520
            Mouse   546  545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..166	CDD:462433	38/151 (25%)
		NrfG	179..>256	CDD:443378	20/119 (17%)
		TPR repeat	179..213	CDD:276809	10/69 (14%)
		TPR repeat	218..248	CDD:276809	6/36 (17%)
		P4Hc	339..510	CDD:214780	72/174 (41%)
P4ha3	XP_006508007.1	P4Ha_N	31..158	CDD:462433	37/139 (27%)
		P4Hc	363..535	CDD:214780	72/174 (41%)