DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaPV and CG31524

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	181/531 - (34%)
Similarity:	283/531 - (53%)	Gaps:	21/531 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LPVRVLLTYQVLLLLLRQAKGEESH---CTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRR 69
            :||..||...:..|.|...:.|.:.   ..||..|..||::|..|:..||.||.:|..|..|:|.
  Fly     1 MPVLKLLFVVIFFLSLSMGQIEATQPRFARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRW 65

  Fly    70 SITSLRLENDKARSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREHMPT 134
            .|..:|.:.||   |.:|...:..|.:|.||.|..||::|:.|:|.||...::...|.....||.
  Fly    66 GIQQMREQLDK---SKKEQSFDLFNRYSFIRHMQADWLMWKQYLDKPVIRDELNYKQMDNLRMPQ 127

  Fly   135 HTDVEEAVTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIY 199
            ..|:.:|..|:.|:|:||.:...:|:.|||:|.||...|:.:|..|||:.|.:|..:..|..||.
  Fly   128 ELDLFDASEAIRRMQATYAMLSNDIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQWIL 192

  Fly   200 QSVVLMEAFSMAAPLEISKNEVRMVYAETLLKL----NQHADALKVVNIALTDNPHDIKLLLKKS 260
            ..:...:.......:.:.:...:.....||.|:    .....|||....||..:|||:::..:..
  Fly   193 AGIKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFERRNEEGALKAYQAALKHSPHDLEIFQEYQ 257

  Fly   261 EIETMIRTGTNNAPPVK------VQATGVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAP 319
            .::..:.| .:.:.|::      ::...:|......|.|   |...::|||:||..|:|||.|||
  Fly   258 NLKRRVLT-LSPSEPIREEPNDDIEEMELPPCCSGRCEG---PRKLNRLYCVYNCVTAPFLRLAP 318

  Fly   320 LKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGY 384
            :|.|::.:||:::|.||::|.||...::..:...:..:....|:: ..|:.|.||||..||....
  Fly   319 IKTEILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVNAAN-EFEIAKFRTSKSVWFDSDA 382

  Fly   385 NPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAMSGDRIATVLFYL 449
            |..|::|..|:.:.||.::..||..|::|||:||.::.|:|..............||:||.||||
  Fly   383 NEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADEDRFVNGYIDRLATTLFYL 447

  Fly   450 TDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQ 514
            .||.|||||.||.:...|||:.|:|:|||||...|.:..:|:|..||||||||||.:|||.::.|
  Fly   448 NDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVVSKWIDDKGQ 512

  Fly   515 IFSRPCLKKRM 525
            .|.||||:.|:
  Fly   513 EFRRPCLRSRL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	45/128 (35%)
		TPR_11	179..250	CDD:290150	16/74 (22%)
		TPR repeat	179..213	CDD:276809	8/33 (24%)
		TPR repeat	218..248	CDD:276809	8/33 (24%)
		P4Hc	339..510	CDD:214780	70/170 (41%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	45/128 (35%)
		TPR_11	215..>259	CDD:290150	11/43 (26%)
		TPR_2	216..249	CDD:285020	9/32 (28%)
		P4Hc	340..507	CDD:214780	68/167 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461771
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900