DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and P4htm

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_217285.7	Gene:	P4htm / 301008	RGDID:	1311848	Length:	503	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	108/500 - (21%)
Similarity:	170/500 - (34%)	Gaps:	167/500 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 YLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTY 152
            ||.|.|.....:...|.|      ...||.        .:.||..|........:|.|:.|:..|
  Rat    72 YLGNVLALLLFVHYSNGD------ESTDPG--------PQRREQSPQPVPTLGPLTRLEGIKVGY 122

  Fly   153 GLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEIS 217
            ..||..::     |:.:     .:.|.::..:||:...:|:               .....|.|.
  Rat   123 ERKVQVVA-----GRDH-----FIRTLSLKPLLFEIPGFLS---------------DEECRLIIH 162

  Fly   218 KNEVRMVYAETLLKLNQHADALKVVNIA------LTDNPHDIKLLLKKSEIETMIRTGTNNAPPV 276
            ..:::.:....:|...::.:|:..:.::      |.|..||.:|.|::...:|.:..|.
  Rat   163 LAQMKGLQRSQILPTEEYEEAMSAMRVSQLDLFQLLDQNHDGRLQLREVLAQTRLGNGR------ 221

  Fly   277 KVQATGVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPK 341
                             ...|....::|             :.:|.:..|        ..|||
  Rat   222 -----------------WMTPENIQEMY-------------SAIKADPDG--------DGVLS-- 246

  Fly   342 EIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTV------------RLNAR 394
                ||..:...|:....|..|.........|.|...|...|.....|            ||:..
  Rat   247 ----LQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLHQGEGAHHVMRAIRQRVLRLTRLSPE 307

  Fly   395 ISDMTGFNLYGSEMLQLMNYGLGGHYDQHYD---FFNKT---------NSNMTAMSGDRIATVLF 447
            |.::       ||.||::.||.||||..|.|   .:.:|         |.::...:..|..||||
  Rat   308 IVEL-------SEPLQVVRYGEGGHYHAHVDSGPVYPETVCSHTKLVANESVPFETSCRYMTVLF 365

  Fly   448 YLTDVEQGGATVFP-----------------------------NIRKAVFPQRGSVVMWYNLKDN 483
            ||.:|..||.||||                             |:|  |.||:|:.|.|||...:
  Rat   366 YLNNVTGGGETVFPVADNRTYDEMSLIQDNVDLRDTRRHCDKGNLR--VKPQQGTAVFWYNYLPD 428

  Fly   484 GQ-----IDTQTLHAACPVIVGSKWVCNKWI-----REREQIFSR 518
            ||     :|..:||..|.|..|:||:.|.||     |.|:.:|.:
  Rat   429 GQGWVGEVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	17/75 (23%)
		TPR_11	179..250	CDD:290150	9/76 (12%)
		TPR repeat	179..213	CDD:276809	3/33 (9%)
		TPR repeat	218..248	CDD:276809	3/35 (9%)
		P4Hc	339..510	CDD:214780	65/233 (28%)
P4htm	XP_217285.7	EF-hand_7	193..253	CDD:404394	17/109 (16%)
P4htm	XP_217285.7	P4Hc	247..459	CDD:214780	62/220 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840