Protein Alignment PH4alphaPV and P4HA3

DIOPT Version :10

• Sequence 1: NP_733395.1
• Gene: PH4alphaPV / 43640
• FlyBaseID: FBgn0051015
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 144/488 - (29%)
• Similarity: 235/488 - (48%)
• Gaps: 88/488 - (18%)

  Fly    26 AKGEE-SHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEY- 88
            |:|:. |..||||   :.|..|.:|:..|..|....|.:|:.:.|..       ||..|..|:.
Human    26 ARGDTFSALTSVA---RALAPERRLLGLLRRYLRGEEARLRDLTRFY-------DKVLSLHEDST 80

  Fly    89 --LSNPLNSFSLIRRMNRDW--IIWQLYMDDPV-----GISQVERIQELREHMPTHTDVEEAVTA 144
              ::|||.:|:||:|:..||  ::..|...:.:     |..:||      :.:|...|:|.|..|
Human    81 TPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVE------QDLPAFEDLEGAARA 139

  Fly   145 LDRIQSTYGLKVPEISHGF-----------LNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWI 198
            |.|:|..|.|.|..::.|.           |...:...|||..|.:.:|::.:|..:|..|..|:
Human   140 LMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWL 204

  Fly   199 YQSVVLMEA------FSMAAPLEISKNEVRMVYAETLLKLNQHADALKVVNIALTDNPHDIKLLL 257
            .::|.|...      ....|.||.:.:.:...|    .:....:.||.:....|..:|.:.::..
Human   205 EEAVSLFRGSYGEWKTEDEASLEDALDHLAFAY----FRAGNVSCALSLSREFLLYSPDNKRMAR 265

  Fly   258 KKSEIETMIRTGTN-----------NAPPVKVQAT---------GVPTAYQIGCRGQFPPSADSK 302
            ...:.|.::....|           |.|.::.:.|         ..||.|||       ||
Human   266 NVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQI-------PS---- 319

  Fly   303 LYCLYNRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRN 367
            |||.|...::.:|:|.|::.|::.|:||:.||||.:|..|.::::.:|.|.|:|:.|   :||..
Human   320 LYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAEPWLQRSVV---ASGEK 381

  Fly   368 EV-VKTRTSKVAWFPDGYNPLTVRLNARISDMTGFNL---YGSEMLQLMNYGLGGHYDQHYDFFN 428
            :: |:.|.||.||..|..:|..|.||.||:.:||.::   | :|.||::|||:||||:.|:|...
Human   382 QLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPY-AEYLQVVNYGIGGHYEPHFDHAT 445

  Fly   429 KTNSNMTAM-SGDRIATVLFYLTDVEQGGATVF 460
            ..:|.:..| ||:|:||.:.||:.||.||||.|
Human   446 SPSSPLYRMKSGNRVATFMIYLSSVEAGGATAF 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..166	CDD:462433	41/151 (27%)
		NrfG	179..>256	CDD:443378	15/82 (18%)
		TPR repeat	179..213	CDD:276809	7/39 (18%)
		TPR repeat	218..248	CDD:276809	4/29 (14%)
		P4Hc	339..510	CDD:214780	53/127 (42%)
P4HA3	NP_001275677.1	P4Ha_N	58..160	CDD:462433	32/114 (28%)
		BepA	<188..289	CDD:443813	17/104 (16%)
		P4Hc	356..>478	CDD:214780	52/125 (42%)