DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and C14E2.4

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001359861.1	Gene:	C14E2.4 / 182616	WormBaseID:	WBGene00015773	Length:	311	Species:	Caenorhabditis elegans

Alignment Length:	233	Identity:	57/233 - (24%)
Similarity:	92/233 - (39%)	Gaps:	65/233 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 LKMELVGLDPYMVLYHDVLSPKEI-----------------------------KELQGMATPGLK 355
            ::||::...|.:|:|.||.|.|::                             ::..|..||...
Worm    81 VRMEILSWSPPLVIYRDVFSKKQVSDYLELLKNLKMNEQKVVRDDGEIAYSTYRQANGTITPAHS 145

  Fly   356 RATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHY 420
            .|   :|.|    ::.|.|..:..|...|                     :|.:..::|..||||
Worm   146 HA---EAQS----LMDTATQLLPVFDFQY---------------------TEQISALSYIKGGHY 182

  Fly   421 DQHYDFF---NKTNSNM-TAMSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLK 481
            ..|.||.   |..:||. ....|:|:||.:......|:||.|:||.:........|...:|:|..
Worm   183 ALHTDFLTFANAEDSNRHFGEMGNRLATFIMVFKKAEKGGGTLFPQLGNVFRANPGDAFLWFNCN 247

  Fly   482 DNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRP 519
            .|.:.:.::||..||:..|.|.:...|||    ||::|
Worm   248 GNLEREAKSLHGGCPIRAGEKIIATIWIR----IFNQP 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528
		TPR_11	179..250	CDD:290150
		TPR repeat	179..213	CDD:276809
		TPR repeat	218..248	CDD:276809
		P4Hc	339..510	CDD:214780	45/203 (22%)
C14E2.4	NP_001359861.1	P4Hc	100..276	CDD:214780	45/203 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.720