DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaPV and phy-2

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_502317.1	Gene:	phy-2 / 178170	WormBaseID:	WBGene00004025	Length:	539	Species:	Caenorhabditis elegans

Alignment Length:	520	Identity:	181/520 - (34%)
Similarity:	283/520 - (54%)	Gaps:	22/520 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VLLLLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEK-KLQTVRRSITSLRLENDKA 81
            |||:.|..........|::|.:..:|..|..:...::.| :|.|: :|..:||........|..|
Worm     4 VLLVCLLAGLAHADLFTAIADLQHMLGAEKDVTTIIDQY-IEAERARLDDLRRYAHEYVHRNAHA 67

  Fly    82 RSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREH----MPTHTDVEEAV 142
            .|...|:::||:|::.||:|:..:|...:..|.:....:.::.|.:.|..    .|...|:..|.
Worm    68 ESVGPEFVTNPINAYLLIKRLTTEWKKVENIMLNNKASTFLKNITDNRVRSEVKFPGEEDLSGAA 132

  Fly   143 TALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEA 207
            |||.|:|.||.|...::|:|.:.|::.:..|:..||:.:|:..::||:|.....|:..::|.:|.
Worm   133 TALLRLQDTYSLDTLDLSNGIIGGEKVSNKLSGHDTFEVGRSAYNQKDYYHCLMWMQVALVKIEN 197

  Fly   208 FSMAAPLEISKNEVRMVYAETLLKLNQHADALKVVNIALTDNPHDIKLLLKKSEIETMI--RTGT 270
            .:   |..|.:.|:....|.:|.:......||.:........|:..:........|.|:  :...
Worm   198 EN---PPTIEEWEILEYLAYSLYQQGNVRRALSLTKRLAKIAPNHPRAKGNVKWYEDMLQGKDMV 259

  Fly   271 NNAPPV---KVQATGV--PTAYQIGCRGQFP---PSADSKLYCLYNRTTSPFLILAPLKMELVGL 327
            .:.||:   :|:..|:  ..||:..|||:.|   |...:||.| |.:...|||.|||:|:|::..
Worm   260 GDLPPIVNKRVEYDGIVERDAYEALCRGEIPPVEPKWKNKLRC-YLKRDKPFLKLAPIKVEILRF 323

  Fly   328 DPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRLN 392
            ||..||:.:|:...||:.::.:|:|.||||||..:.:|..|....|.||.||.....:|:..|:|
Worm   324 DPLAVLFKNVIHDSEIEVIKELASPKLKRATVQNSKTGELEHATYRISKSAWLKGDLDPVIDRVN 388

  Fly   393 ARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSN--MTAMSGDRIATVLFYLTDVEQG 455
            .||.|.|..|...||.||:.|||||||||.|:||..|...|  .|..:|:||||||||::..|:|
Worm   389 RRIEDFTNLNQATSEELQVANYGLGGHYDPHFDFARKEEKNAFKTLNTGNRIATVLFYMSQPERG 453

  Fly   456 GATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRPC 520
            |||||.::..||||.:...:.||||:.:|:.|.:|.||||||::|.|||.||||.|:.|.|:|||
Worm   454 GATVFNHLGTAVFPSKNDALFWYNLRRDGEGDLRTRHAACPVLLGVKWVSNKWIHEKGQEFTRPC 518

Fly 521 520
Worm 519 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	36/133 (27%)
		TPR_11	179..250	CDD:290150	14/70 (20%)
		TPR repeat	179..213	CDD:276809	7/33 (21%)
		TPR repeat	218..248	CDD:276809	5/29 (17%)
		P4Hc	339..510	CDD:214780	84/172 (49%)
phy-2	NP_502317.1	P4Ha_N	21..154	CDD:285528	36/133 (27%)
		TPR_16	169..240	CDD:290168	15/73 (21%)
		P4Hc	335..508	CDD:214780	84/172 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770