Protein Alignment PH4alphaPV and dpy-18

DIOPT Version :10

• Sequence 1: NP_733395.1
• Gene: PH4alphaPV / 43640
• FlyBaseID: FBgn0051015
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_499464.1
• Gene: dpy-18 / 176569
• WormBaseID: WBGene00001077
• Length: 559
• Species: Caenorhabditis elegans
• Alignment Length: 521
• Identity: 163/521 - (31%)
• Similarity: 250/521 - (47%)
• Gaps: 53/521 - (10%)

  Fly    34 TSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPLNSFSL 98
            ||:|.|..||:.|..:...|:.|..:.|::|..:::.......:|:.:..:..:.::||:|:|.|
 Worm    20 TSIADMQNLLETERNIPKILDKYIHDEEERLVQLKKLSEEYSKKNEISIENGLKDITNPINAFLL 84

  Fly    99 IRRMNRDWIIWQLYM-------------DDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQS 150
            |:|...||...:..|             ||..|:           ..||..|:..|...|.|:|.
 Worm    85 IKRKIFDWKEIESKMNANKAGNVVSSITDDSYGV-----------RYPTADDLSGAAIGLLRLQD 138

  Fly   151 TYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLE 215
            ||.|...:::.|.:...|.|.:.:..|.:.:.:..:::.::       |.:|:.||........|
 Worm   139 TYRLDTKDLADGKIYADQGNYTFSAKDCFEIARAAYNEHDF-------YHTVMWMEEAQRRLGDE 196

  Fly   216 ISK----NEVRMVYAETLLKLNQHADALKVVNIALTDNP-H-----DIKLLLKKSEIETMIRTG- 269
            :..    .::....|..|.|.|....|||:.......|| |     ::|......|.|.:.|:.
 Worm   197 VEPTVEVEDILEYLAFALYKQNNLKHALKLTEELYKMNPTHPRAKGNVKWYEDLLEQEGVRRSDM 261

  Fly   270 TNNAPPVK------VQATGVPTAYQIGCRGQFPPSAD--SKLYCLYNRTTSPFLILAPLKMELVG 326
            ..|.||::      |......|.|:..||.:.|.|..  |:|||.|.| ..|||:.||:|:|:..
 Worm   262 RKNLPPIQNRRPDSVLGNTERTMYEALCRNEVPVSQKDISRLYCYYKR-DRPFLVYAPIKVEIKR 325

  Fly   327 LDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRL 391
            .:|..||:.||:|..|:..:|.:|.|.|.||||:.:.:|:......|.||.||..:....:...:
 Worm   326 FNPLAVLFKDVISDDEVAAIQELAKPKLARATVHDSVTGKLVTATYRISKSAWLKEWEGDVVETV 390

  Fly   392 NARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNM--TAMSGDRIATVLFYLTDVEQ 454
            |.||..||...:..:|.||:.|||:|||||.|:|...|..|..  :..:|:||||||||::....
 Worm   391 NKRIGYMTNLEMETAEELQIANYGIGGHYDPHFDHAKKEESKSFESLGTGNRIATVLFYMSQPSH 455

  Fly   455 GGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRP 519
            ||.|||...:..:.|.:...:.||||...|..:..|.||||||:||.|||.||||.|:...|.||
 Worm   456 GGGTVFTEAKSTILPTKNDALFWYNLYKQGDGNPDTRHAACPVLVGIKWVSNKWIHEKGNEFRRP 520

  Fly   520 C 520
            |
 Worm   521 C 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..166	CDD:462433	35/143 (24%)
		NrfG	179..>256	CDD:443378	16/86 (19%)
		TPR repeat	179..213	CDD:276809	4/33 (12%)
		TPR repeat	218..248	CDD:276809	7/33 (21%)
		P4Hc	339..510	CDD:214780	71/172 (41%)
dpy-18	NP_499464.1	P4Ha_N	21..152	CDD:462433	35/141 (25%)
		NrfG	150..>240	CDD:443378	19/96 (20%)
		P4Hc	338..511	CDD:214780	71/172 (41%)