DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and p4ha1

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	518	Identity:	176/518 - (33%)
Similarity:	271/518 - (52%)	Gaps:	50/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPLNSFSL 98
            ||:..|:.||:.|..|:.:|:||....|:||..:::....|....|.|....|.||.:|:|:|.|
Frog    22 TSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLTDTATKDPEGYLGHPVNAFKL 86

  Fly    99 IRRMNRDWI-IWQLYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTYGLKVPEISHG 162
            ::|:|.:|: :..|.:.| :....:..:...|::.|...|...|..||.|:|.||.|....||.|
Frog    87 MKRLNTEWVKLENLILKD-ISDGFISNLTIQRQYFPNDEDQTGAAKALLRLQDTYNLDTDTISKG 150

  Fly   163 FLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEISKNEVRMVYAE 227
            .|.|.::..|||..|.:.:|:..:...:|.....|:.|::..::|..     |.|.::| ||...
Frog   151 NLPGVKHKTSLTAEDCFDLGKTAYTDADYYHTELWMEQALSQLDAGE-----ESSLDKV-MVLDY 209

  Fly   228 TLLKLNQHADALKVVNIALTDNPHDIKLLLKKS-EIETMIRTGTNNAPPVKVQATGVPTA----- 286
            ....:.|..|..|    |||        |.|:| |::...:.|..|...:..:.:...::
Frog   210 LSYAVYQQGDLDK----ALT--------LTKRSLELDPEHQRGNGNLRHIMSKESNKSSSSPSEG 262

  Fly   287 ------------------YQIGCRGQ---FPPSADSKLYCLY-NRTTSPFLILAPLKMELVGLDP 329
                              |:..|||:   .......:|:|.| :....|.|||:|.|.|.....|
Frog   263 AELRTRKGRPKDHLEKEKYEKLCRGEGVKMTSRRQKRLFCRYFDGKKDPLLILSPTKQEDEWDKP 327

  Fly   330 YMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNAR 394
            .:|.|||::|.:||.:::.:|.|.|:|||:....:|..|..:.|.:|.||.....:|:..|||.|
Frog   328 RIVRYHDIISDEEISKVKELAKPRLRRATISNPITGVLETAQYRITKSAWLSGYEDPVVARLNRR 392

  Fly   395 ISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAM--SGDRIATVLFYLTDVEQGGA 457
            |..:||.::..:|.||:.|||:||.|:.|:||..|...:....  :|:|:||.|||::|||.|||
Frog   393 IEGVTGLDMSTAEELQVANYGIGGQYEPHFDFLRKYEPDAFKKLGTGNRVATWLFYMSDVEAGGA 457

  Fly   458 TVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRPC 520
            ||||.:..||:|::|:.|.||||.::|:.|..|.||||||:||:|||.||||.||.|.|.|||
Frog   458 TVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLVGNKWVSNKWIHERGQEFRRPC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	41/129 (32%)
		TPR_11	179..250	CDD:290150	16/70 (23%)
		TPR repeat	179..213	CDD:276809	5/33 (15%)
		TPR repeat	218..248	CDD:276809	8/29 (28%)
		P4Hc	339..510	CDD:214780	79/172 (46%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	26/87 (30%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	79/172 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110