Protein Alignment CG31021 and P4HA2

DIOPT Version :9

• Sequence 1: NP_733392.2
• Gene: CG31021 / 43638
• FlyBaseID: FBgn0051021
• Length: 453
• Species: Drosophila melanogaster
• Sequence 2: NP_001136071.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 127/502 - (25%)
• Similarity: 212/502 - (42%)
• Gaps: 72/502 - (14%)

  Fly     1 MLNLERNLLQNMRDYAEKLEEKIDLINNYVEDYNVDIEDANEDPEKYLSNPLNSFRLIRHMHQDW 65
            ::..|:.|:|::::|....|.|:..|.::..........:..|.|.||::|:|:::|::.::.||
Human    33 LIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDW 97

  Fly    66 VGWQVYMEDLVAPE-AVQKVESLLPQ---LPQKEAFRKAARSVHSLTQFYGYEPADLVAKDERSS 126
            ..    :||||..: |...:.:|..|   .|..|....||:::..|...|..:|. .:::.|...
Human    98 PA----LEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPG-TISRGELPG 157

  Fly   127 SLH---LSPLDCYHLGLELYEEQDYLGAAKWL-----QVAAHNYTLSRHRDLFNPLGAPRWQVYR 183
            :.:   ||..||:.:|...|.|.||.....|:     |:.|.....:....:.:.|....:|: .
Human   158 TKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQL-G 221

  Fly   184 DLGRTLLKLNRQCAYD-AYESA---LR-----LNSQNVHLMKEAGQMELFSLRDPMEPILDLQPK 239
            ||.|.|....|..:.| ::|.|   ||     |..:....:....:.||.:.....|..:|..|:
Human   222 DLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPE 286

  Fly   240 PTVLEKYCRGE----VPRHQGRLTCELNDWVHS----FLAYAPIKFEDLQQDPFIILYPGSIYEQ 296
            ..|.|..||||    .||.|.||.|..:   |.    .|..||.|.||....|.|:.|...:.::
Human   287 RDVYESLCRGEGVKLTPRRQKRLFCRYH---HGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDE 348

  Fly   297 EIRHVENAYE----RCPPNDRFELKLGISGCSIS------DGYSPVLKRINERILDMAGVE-KTW 350
            ||..::...:    |....|.....|.::...:|      :...||:.|:|.|:..:.|:. ||.
Human   349 EIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTA 413

  Fly   351 DTFYIVEYAQLAPFEP-FKLFRNSTK--FPKLNLMNFEDVEAKVIIFL---KDVTLGGAFTMPNG 409
            :...:..|.....:|| |...||..:  |..|...|      :|..||   .||..|||...|:.
Human   414 ELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGN------RVATFLNYMSDVEAGGATVFPDL 472

  Fly   410 DILVQPKRG------NVLITFENE---EHSTTICPIIEGTGLVMIKF 447
            ...:.||:|      |:|.:.|.:   .|:.  ||::.|...|..|:
Human   473 GAAIWPKKGTAVFWYNLLRSGEGDYRTRHAA--CPVLVGCKWVSNKW 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31021	NP_733392.2	P4Ha_N	1..119	CDD:285528	30/121 (25%)
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	30/126 (24%)
		TPR	207..240		8/33 (24%)
		P4Hc	346..519	CDD:214780	44/180 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.040