DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31021 and P4HTM

DIOPT Version :9

Sequence 1:	NP_733392.2	Gene:	CG31021 / 43638	FlyBaseID:	FBgn0051021	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	300	Identity:	62/300 - (20%)
Similarity:	97/300 - (32%)	Gaps:	92/300 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLNLERNLLQNMRDYAEKLE----EKIDLINNYVEDYNVDIEDANEDPEKYLSNPLNSFRLIRHM 61
            |..|:|:.:....:|.|.:.    .::||..         :.|.|.|....|...|...||..
Human   165 MKGLQRSQILPTEEYEEAMSTMQVSQLDLFR---------LLDQNRDGHLQLREVLAQTRLGN-- 218

  Fly    62 HQDWVGWQVYMEDLVAPEAVQKVESLLPQLPQKEAFRKAARSVHSLTQFYGYEPADLVAKDERSS 126
                 ||      .:.||::|::.:.:...|..:       .|.||.:|...:..|. .|..||.
Human   219 -----GW------WMTPESIQEMYAAIKADPDGD-------GVLSLQEFSNMDLRDF-HKYMRSH 264

  Fly   127 SLHLSPL--DCYHLGLELYEEQDYLGAAKWLQVAAHNYTLSRHR------------DLFNPLGAP 177
            ....|.|  :.:|..|       |.|     :.|.|.....|.|            :|..||...
Human   265 KAESSELVRNSHHTWL-------YQG-----EGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVV 317

  Fly   178 R------WQVYRDLG----RTLLKLNRQCAYDA--YESALRLNSQNVHLMKEAGQMELFSLRDPM 230
            |      :..:.|.|    .|:....:..|.::  :|::.|..|.|         ..|.|:..|.
Human   318 RYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPN---------WGLPSILRPG 373

  Fly   231 EPILDLQPKPTVLEKYCRGEVPRHQG---RLTCELNDWVH 267
            .|:...||        |...||...|   .....::.|.|
Human   374 TPMTQAQP--------CTVGVPLGMGPGDHWVIPVSPWEH 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31021	NP_733392.2	P4Ha_N	1..119	CDD:285528	25/121 (21%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		EF-hand_7	192..252	CDD:290234	19/88 (22%)
		EFh	194..252	CDD:238008	17/86 (20%)
		P4Hc	246..519	CDD:214780	39/189 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830