DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31021 and CG15539

DIOPT Version :9

Sequence 1:	NP_733392.2	Gene:	CG31021 / 43638	FlyBaseID:	FBgn0051021	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	114/495 - (23%)
Similarity:	213/495 - (43%)	Gaps:	77/495 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLNLERNLLQNMRDYAEKLEEKIDLINNYVE--DYNVDIEDANEDPEKYLS-NPLNSFRLIRHMH 62
            :::.|..||..::.:|..|::::|.:..|:|  ||         |.||.|: :|:..||:.|.:|
  Fly    40 LIDYEHYLLNILQKFANALQKRVDTLEYYLEMTDY---------DREKNLAEDPIKHFRITRRLH 95

  Fly    63 QDWVGWQVYMEDLVAPEAVQKVESLLPQLPQKEAFRKAARSVHSLTQFYGYEPADLVAKDERSSS 127
            .|:|.|..:||:......|:.:.::.|::|..:...:|.|.:..:...|....|:: ||......
  Fly    96 SDYVNWVWFMEEQPWGTLVKDIIAIAPEMPTLKDVEEAIRGLRLIQWTYSLPTAEM-AKGVLQDI 159

  Fly   128 LHLSPLD---CYHLGLELYEEQDYLGAAKWLQVAAHNYTLSRHRD-LFNPLGAPRWQVYR----- 183
            .|.:.||   |..:...:...:|::.|.:||.|....|......: :::.||.|....|.
  Fly   160 HHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADEEIEYIYSQLGMPLVDFYELFVEI 224

  Fly   184 --DLGRTLLKLNRQCAYDAYESALRLNSQNVHLMKEAGQMELFSLRDPMEPILDLQPKPTVLEKY 246
              :||      :|..|....:.|::...:.|.|.:...:::: ::|...||.........|.:|.
  Fly   225 QDELG------SRYLAMSELQLAIKNWPEKVSLQRALSRLKM-NIRIGKEPAEKKNKSKRVYKKC 282

  Fly   247 CRGEVPRHQGRLTCELNDWVHSFLAYAPIKFEDLQQDPFIILYPGSIYEQEIRHVENAYERCPPN 311
            |..|. |...:|.|........||..||:|.|.|..||:::|:...:.:::|..:.|..:.
  Fly   283 CSSEC-RPTAKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKG---- 342

  Fly   312 DRFELKLGISGCSISDG-----------------YSPVLKRINERILDMAGVE-KTWDTFYIVEY 358
                 ||..:.....||                 .:.:::|:::...||...: ...|.|.::.|
  Fly   343 -----KLARTVTVSKDGNYTEDPDRTTKGTWLVENNALIQRLSQLTQDMTNFDIHDADPFQVLNY 402

  Fly   359 AQLAPFE--PFKLFRNSTKFPKLNLMNFEDVEAKVIIFLKDVTLGGAFTMPNGDILVQPKRGNVL 421
            . :..|.  .|....::      .|.||.|..|..:.:|.||..|||...|...:.|.||:|:.|
  Fly   403 G-IGGFYGIHFDFLEDA------ELDNFSDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSAL 460

  Fly   422 ITFENEEH--------STTICPIIEGTGLVMIKFIMKTDE 453
            :.: |.:|        :.:.||.:.|:..||.|:|.:.::
  Fly   461 LWY-NLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQ 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31021	NP_733392.2	P4Ha_N	1..119	CDD:285528	31/120 (26%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/125 (26%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	39/181 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990