DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31021 and p4ha2

DIOPT Version :9

Sequence 1:	NP_733392.2	Gene:	CG31021 / 43638	FlyBaseID:	FBgn0051021	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	538	Identity:	120/538 - (22%)
Similarity:	218/538 - (40%)	Gaps:	131/538 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLNL---ERNLLQNMRDYAEKLEEKIDLINNYVEDYNVDIEDANEDPEKYLSNPLNSFRLIRHMH 62
            |.||   ||.|:|::::|.:..|:|::.:.::....:.....:..|||.:|::|:|:::|::.::
Zfish    29 MTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLDKLTRTSTSDPEGFLAHPVNAYKLMKRLN 93

  Fly    63 QDWVGWQVYMEDLVAPEAVQKVESLLPQ----------------LPQKEAFRKAARSVHSLTQFY 111
            .:|                .::|||:.|                .|.:|..:.||:::..|...|
Zfish    94 TEW----------------SELESLVLQDPSDGFISNMSVHRQYFPDEEDEKGAAKALLRLQDTY 142

  Fly   112 ---------GYEPADLVAKDERSSSLHLSPLDCYHLGLELYEEQDYLGAAKWLQVAAHNYTLSRH 167
                     |..|........|.::| |:..||:.:|...|.:.||..:..|:|.:.      |.
Zfish   143 KLDAESFSKGKLPGQRQHSGVRYNAL-LTVDDCFDMGKMAYNDNDYYHSVLWMQQSL------RQ 200

  Fly   168 RDLFNPLGAPR--------WQVYR--DLGRTLLKLNRQCAYD-AYESA-------LRLNSQNVHL 214
            .|.......|:        :.||:  ||.|.:....|..|.| :::.|       .||.|:.
Zfish   201 MDSGEEAKTPKADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQRAGGNLRYFERLLSKE--- 262

  Fly   215 MKEAGQ----------MELFSLRDPMEPILDLQPKPTVLEKYCRGE----VPRHQGRLTCELNDW 265
            ::::||          ::|.:.:.|.    |..|:....|..||||    ..:.|.||.|...|.
Zfish   263 LQDSGQTQPEPADERPIQLDTYQRPK----DYLPEREAYEALCRGEGVKMTTKRQSRLFCRYRDG 323

  Fly   266 VHS-FLAYAPIKFEDLQQDPFIILYPGSIYEQEIRHVE--------NAYERCPPNDRFELKLG-- 319
            ..: .|...|:|.||....|.|:.:..::.::||:.::        .|..|.|       |.|
Zfish   324 NRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDP-------KTGVL 381

  Fly   320 ------ISGCSISDGY-SPVLKRINERILDMAGVEKTWDT---FYIVEYAQLAPFEPFKLFRNST 374
                  :|..:..:|. .||:.|:|:||.|:.|:  |.||   ..:..|.....:||...|....
Zfish   382 TVAHYRVSKSAWLEGEDDPVIARVNQRIEDITGL--TVDTAELLQVANYGVGGQYEPHFDFSRKD 444

  Fly   375 KFPKLNLMNFEDVEAKVIIFLKDVTLGGAFTMPNGDILVQPKRGNVLITFE---------NEEHS 430
            :......:...:..|..:.::.||..|||...|:....|.|::|..:..:.         ...|:
Zfish   445 EPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGDYRTRHA 509

  Fly   431 TTICPIIEGTGLVMIKFI 448
            .  ||::.|:..|..|:|
Zfish   510 A--CPVLVGSKWVSNKWI 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31021	NP_733392.2	P4Ha_N	1..119	CDD:285528	30/145 (21%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	29/140 (21%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	41/184 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940