DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2246 and PRPSAP2

DIOPT Version :9

Sequence 1:	NP_001189321.1	Gene:	CG2246 / 43637	FlyBaseID:	FBgn0039790	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001340027.1	Gene:	PRPSAP2 / 5636	HGNCID:	9467	Length:	423	Species:	Homo sapiens

Alignment Length:	399	Identity:	246/399 - (61%)
Similarity:	305/399 - (76%)	Gaps:	36/399 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VRPPKRCRSDMDNTSTSDIVIINGNSHP---DLANMVAERMGIKNGGCSVFHKSNRETIVEISDS 72
            |.||: ..:.| |.:...:|:.:.||:.   :|:..:|||:|::.|...|:.:.||||.|:|.:|
Human    58 VTPPE-LETKM-NITKGGLVLFSANSNSSCMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQES 120

  Fly    73 VRGKDIYIIQTGTKDANNNIMELLIMAYACKTSSARSIVGVIPYLPYSKQCKMRKRGCIVSKLLA 137
            |||||::||||.:||.|..|||||||.||||||.|:||:|||||.||||||||||||.|||||||
Human   121 VRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVSKLLA 185

  Fly   138 KMMCTSGLTHIITMDLHQKEIQGFFDIPVDNLRASPFLLQYIQESIPDYRNSVIVARNPGVAKKA 202
            .|||.:||||:||||||||||||||:||||||||||||||||||.||||||:||||::|..||:|
Human   186 SMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRA 250

  Fly   203 NSYAERLRLGLAVIHGEQKETDADEVDGRYSPPPTSAYSNLLGNSVEMCLPATPRNSTPQHAPTS 267
            .|:|||||||:||||||.::.::|.||||:|||        :..||....|
Human   251 QSFAERLRLGIAVIHGEAQDAESDLVDGRHSPP--------MVRSVAAIHP-------------- 293

  Fly   268 SARQRTTSVSVGVPEHIVKVKPPLTIVGDVSGRIAIMVDDLIDDVQAFVAAAEMLKENGACKIYV 332
                     |:.:|..|.|.|||:|:||||.|||||:|||:||||.:|:||||.|||.||.||:|
Human   294 ---------SLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFV 349

  Fly   333 LATHGLLSSDAPRQLDESPIDEIVVTNTIPHEIQKLQCHKIKTIDISILIAEAIRRIHNKESMSY 397
            :||||||||||||:::||.|||:|||||||||:|||||.||||:|||::::||||||||.|||||
Human   350 MATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSY 414

  Fly   398 LFRNVTLED 406
            ||||:.|:|
Human   415 LFRNIGLDD 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2246	NP_001189321.1	PrsA	25..400	CDD:223538	236/377 (63%)
		Pribosyltran_N	29..144	CDD:290508	72/117 (62%)
		Pribosyl_synth	185..400	CDD:291252	126/214 (59%)
PRPSAP2	NP_001340027.1	Pribosyltran_N	74..192	CDD:316325	72/117 (62%)
PRPSAP2	NP_001340027.1	Pribosyl_synth	233..417	CDD:291252	126/214 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147741
Domainoid	1	1.000	243	1.000	Domainoid score	I2218
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2073
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1513
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60704
OrthoDB	1	1.010	-	-		D1043963at2759
OrthoFinder	1	1.000	-	-		FOG0005165
OrthoInspector	1	1.000	-	-		otm41910
orthoMCL	1	0.900	-	-		OOG6_104788
Panther	1	1.100	-	-	LDO	PTHR10210
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3063
SonicParanoid	1	1.000	-	-		X3683
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800