Protein Alignment CG2246 and PRPSAP1

DIOPT Version :9

• Sequence 1: NP_001189321.1
• Gene: CG2246 / 43637
• FlyBaseID: FBgn0039790
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_002757.2
• Gene: PRPSAP1 / 5635
• HGNCID: 9466
• Length: 385
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 230/399 - (57%)
• Similarity: 289/399 - (72%)
• Gaps: 41/399 - (10%)

  Fly    11 VRPPKRCRSDMDNTSTSDIVIINGNSH---PDLANMVAERMGIKNGGCSVFHKSNRETIVEISDS 72
            |.||..      |.:.:...:.:.||.   .:||..:.||:|.:.|...|:.::|.||.|||.:|
Human    25 VPPPAM------NAARTGYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGETRVEIKES 83

  Fly    73 VRGKDIYIIQTGTKDANNNIMELLIMAYACKTSSARSIVGVIPYLPYSKQCKMRKRGCIVSKLLA 137
            |||:||:||||..:|.|..:|||||||||.||:.||:|:|||||.|||||.||||||.||.||||
Human    84 VRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLA 148

  Fly   138 KMMCTSGLTHIITMDLHQKEIQGFFDIPVDNLRASPFLLQYIQESIPDYRNSVIVARNPGVAKKA 202
            .|:..:|||||||||||||||||||..|||||||||||||||||.||:|||:||||::|..||:|
Human   149 SMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPDAAKRA 213

  Fly   203 NSYAERLRLGLAVIHGEQKETDADEVDGRYSPPPTSAYSNLLGNSVEMCLPATPRNSTPQHAPTS 267
            .||||||||||||||||.:.|:.|..|||:|||
Human   214 QSYAERLRLGLAVIHGEAQCTELDMDDGRHSPP-------------------------------- 246

  Fly   268 SARQRTTSVSVGVPEHIVKVKPPLTIVGDVSGRIAIMVDDLIDDVQAFVAAAEMLKENGACKIYV 332
            ..:..|....:.:|..:.|.|||:|:||||.|||||:|||:||||::||||||:|||.||.||||
Human   247 MVKNATVHPGLELPLMMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYV 311

  Fly   333 LATHGLLSSDAPRQLDESPIDEIVVTNTIPHEIQKLQCHKIKTIDISILIAEAIRRIHNKESMSY 397
            :||||:||::|||.::||.:||:|||||:|||:|||||.||||:|||::::||||||||.|||:|
Human   312 MATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAY 376

  Fly   398 LFRNVTLED 406
            ||||:|::|
Human   377 LFRNITVDD 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2246	NP_001189321.1	PrsA	25..400	CDD:223538	221/377 (59%)
		Pribosyltran_N	29..144	CDD:290508	64/117 (55%)
		Pribosyl_synth	185..400	CDD:291252	119/214 (56%)
PRPSAP1	NP_002757.2	PrsA	37..379	CDD:223538	221/373 (59%)
		Pribosyltran_N	38..155	CDD:290508	64/116 (55%)
		Pribosyl_synth	196..379	CDD:291252	119/214 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147740
Domainoid	1	1.000	243	1.000	Domainoid score	I2218
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1513
Isobase	1	0.950	-	0	Normalized mean entropy	S602
OMA	1	1.010	-	-		QHG60704
OrthoDB	1	1.010	-	-		D1043963at2759
OrthoFinder	1	1.000	-	-		FOG0005165
OrthoInspector	1	1.000	-	-		otm41910
orthoMCL	1	0.900	-	-		OOG6_104788
Panther	1	1.100	-	-	O	PTHR10210
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3063
SonicParanoid	1	1.000	-	-		X3683
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750