Protein Alignment CG2246 and PRPS2

DIOPT Version :10

• Sequence 1: NP_733389.2
• Gene: CG2246 / 43637
• FlyBaseID: FBgn0039790
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_001034180.1
• Gene: PRPS2 / 5634
• HGNCID: 9465
• Length: 321
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 156/381 - (40%)
• Similarity: 222/381 - (58%)
• Gaps: 66/381 - (17%)

  Fly    28 DIVIINGNSHPDLANMVAERMGIKNGGCSVFHKSNRETIVEISDSVRGKDIYIIQTGTKDANNNI 92
            :||:.:|:||.||:..||:|:|::.|.......||:||.|||.:||||:|:||||:|..:.|:|:
Human     3 NIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNL 67

  Fly    93 MELLIMAYACKTSSARSIVGVIPYLPYSKQCKMRK----RGCIVSKLLAKMMCTSGLTHIITMDL 153
            ||||||..|||.:|:..:..|||..||::|.|..|    |..|.:||:|.|:..:|..|||||||
Human    68 MELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGESRAPISAKLVANMLSVAGADHIITMDL 132

  Fly   154 HQKEIQGFFDIPVDNLRASPFLLQYIQESIPDYRNSVIVARNPGVAKKANSYAERLRLGLAVIHG 218
            |..:||||||||||||.|.|.:||:|:|:|.:::|.:||:.:.|.||:..|.|:||.:..|:||.
Human   133 HASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHK 197

  Fly   219 EQKETDADEVDGRYSPPPTSAYSNLLGNSVEMCLPATPRNSTPQHAPTSSARQRTTSVSVGVPEH 283
            |:|:  |:|||
Human   198 ERKK--ANEVD------------------------------------------------------ 206

  Fly   284 IVKVKPPLTIVGDVSGRIAIMVDDLIDDVQAFVAAAEMLKENGACKIYVLATHGLLSSDAPRQLD 348
                  .:.:||||..|:||:|||:.|.......||:.|...||.|:|.:.|||:.|..|..:::
Human   207 ------RMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRIN 265

  Fly   349 ESPIDEIVVTNTIPHEIQKLQCHKIKTIDISILIAEAIRRIHNKESMSYLFRNVTL 404
            .:..:.:|||||||.|.:...|.||:.||||:::||||||.||.||:||||.:|.|
Human   266 NAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2246	NP_733389.2	Pribosyltran_N	29..144	CDD:433483	55/118 (47%)
		Pribosyl_synth	185..400	CDD:434046	70/214 (33%)
PRPS2	NP_001034180.1	PrsA	1..317	CDD:440230	153/375 (41%)
		Binding of phosphoribosylpyrophosphate. /evidence=ECO:0000255	215..230		7/14 (50%)