Protein Alignment CG2246 and PRPS1L1

DIOPT Version :10

• Sequence 1: NP_733389.2
• Gene: CG2246 / 43637
• FlyBaseID: FBgn0039790
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_787082.1
• Gene: PRPS1L1 / 221823
• HGNCID: 9463
• Length: 318
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 152/378 - (40%)
• Similarity: 224/378 - (59%)
• Gaps: 63/378 - (16%)

  Fly    28 DIVIINGNSHPDLANMVAERMGIKNGGCSVFHKSNRETIVEISDSVRGKDIYIIQTGTKDANNNI 92
            :|.|.:|:||.||:..:|:|:|::.|.......||:||.|||.:||||:|:||:|:|..:.|:::
Human     3 NIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGCGEINDSL 67

  Fly    93 MELLIMAYACKTSSARSIVGVIPYLPYSKQCKMRK-RGCIVSKLLAKMMCTSGLTHIITMDLHQK 156
            ||||||..|||.:||..:..|||..||::|.|..| |..|.:||:|.|:..:|..||||||||..
Human    68 MELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAGADHIITMDLHAS 132

  Fly   157 EIQGFFDIPVDNLRASPFLLQYIQESIPDYRNSVIVARNPGVAKKANSYAERLRLGLAVIHGEQK 221
            :||||||||||||.|.|.:|::|:|:||:::|.:||:.:.|.||:..|.|::|.:..|:||.|:|
Human   133 QIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTSIADQLNVDFALIHKERK 197

  Fly   222 ETDADEVDGRYSPPPTSAYSNLLGNSVEMCLPATPRNSTPQHAPTSSARQRTTSVSVGVPEHIVK 286
            :  |:|||                     |
Human   198 K--ANEVD---------------------C----------------------------------- 204

  Fly   287 VKPPLTIVGDVSGRIAIMVDDLIDDVQAFVAAAEMLKENGACKIYVLATHGLLSSDAPRQLDESP 351
                :.:||||:.|:||:|||:.|.......||:.|...||.::|.:.|||:.|..|..:::.:.
Human   205 ----IVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAGATRVYAILTHGIFSGPAISRINTAC 265

  Fly   352 IDEIVVTNTIPHEIQKLQCHKIKTIDISILIAEAIRRIHNKESMSYLFRNVTL 404
            .:.:|||||||.:.:...|.||:.||||:::||||||.||.||:||||.:|.|
Human   266 FEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAIRRTHNGESVSYLFSHVPL 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2246	NP_733389.2	Pribosyltran_N	29..144	CDD:433483	53/115 (46%)
		Pribosyl_synth	185..400	CDD:434046	68/214 (32%)
PRPS1L1	NP_787082.1	PrsA	1..314	CDD:440230	149/372 (40%)
		Binding of phosphoribosylpyrophosphate. /evidence=ECO:0000255	212..227		7/14 (50%)