DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2246 and Prpsap2

DIOPT Version :9

Sequence 1:	NP_001189321.1	Gene:	CG2246 / 43637	FlyBaseID:	FBgn0039790	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001157714.1	Gene:	Prpsap2 / 212627	MGIID:	2384838	Length:	369	Species:	Mus musculus

Alignment Length:	399	Identity:	247/399 - (61%)
Similarity:	304/399 - (76%)	Gaps:	36/399 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VRPPKRCRSDMDNTSTSDIVIINGNSHP---DLANMVAERMGIKNGGCSVFHKSNRETIVEISDS 72
            |.||: ..:.| |.:...:|:.:.||:.   :|:..:|||:|::.|...|:.:.||||.|:|.:|
Mouse     4 VAPPE-LETKM-NITKGGLVLFSANSNSSCMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQES 66

  Fly    73 VRGKDIYIIQTGTKDANNNIMELLIMAYACKTSSARSIVGVIPYLPYSKQCKMRKRGCIVSKLLA 137
            |||||::||||.:||.|..|||||||.||||||.|:||:|||||.||||||||||||.|||||||
Mouse    67 VRGKDVFIIQTISKDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVSKLLA 131

  Fly   138 KMMCTSGLTHIITMDLHQKEIQGFFDIPVDNLRASPFLLQYIQESIPDYRNSVIVARNPGVAKKA 202
            .|||.:||||:||||||||||||||:||||||||||||||||||.||||||:||||::|..||:|
Mouse   132 SMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRA 196

  Fly   203 NSYAERLRLGLAVIHGEQKETDADEVDGRYSPPPTSAYSNLLGNSVEMCLPATPRNSTPQHAPTS 267
            .|:|||||||:||||||.::.::|.||||:|||        :..||....|
Mouse   197 QSFAERLRLGIAVIHGEAQDAESDLVDGRHSPP--------MVRSVAAIHP-------------- 239

  Fly   268 SARQRTTSVSVGVPEHIVKVKPPLTIVGDVSGRIAIMVDDLIDDVQAFVAAAEMLKENGACKIYV 332
                     |:.:|..|.|.|||:|:||||.|||||:|||:||||.:|:||||.|||.||.||:|
Mouse   240 ---------SLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFV 295

  Fly   333 LATHGLLSSDAPRQLDESPIDEIVVTNTIPHEIQKLQCHKIKTIDISILIAEAIRRIHNKESMSY 397
            :||||||||||||.::||.|||:|||||||||||||||.||||:|||::::||||||||.|||||
Mouse   296 MATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSY 360

  Fly   398 LFRNVTLED 406
            ||||:.|:|
Mouse   361 LFRNIGLDD 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2246	NP_001189321.1	PrsA	25..400	CDD:223538	237/377 (63%)
		Pribosyltran_N	29..144	CDD:290508	72/117 (62%)
		Pribosyl_synth	185..400	CDD:291252	127/214 (59%)
Prpsap2	NP_001157714.1	Pribosyltran_N	20..138	CDD:404648	72/117 (62%)
Prpsap2	NP_001157714.1	Pribosyl_synth	179..363	CDD:405288	127/214 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837822
Domainoid	1	1.000	242	1.000	Domainoid score	I2221
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2073
Inparanoid	1	1.050	472	1.000	Inparanoid score	I1493
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60704
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005165
OrthoInspector	1	1.000	-	-		otm43958
orthoMCL	1	0.900	-	-		OOG6_104788
Panther	1	1.100	-	-	LDO	PTHR10210
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3063
SonicParanoid	1	1.000	-	-		X3683
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790