DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9717 and Prestin

DIOPT Version :9

Sequence 1:	NP_651812.1	Gene:	CG9717 / 43636	FlyBaseID:	FBgn0039789	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	133/588 - (22%)
Similarity:	249/588 - (42%)	Gaps:	118/588 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HTNSGFNGGSEVSLDIPT----NTLYHTSRDCIVQEEQGPDESCLEGTQSCCSNLWSNIFRKKTL 69
            :.|:..||||     :|:    ...|...||.:..|............:|..|:| .|.:|....
  Fly    15 NNNTNGNGGS-----VPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSL-RNCWRSWNF 73

  Fly    70 YKRF----PILVWLPQY--KKDYIFGDIVAGISVALTVIPQALAYAGIAGLDLQYGLYACFLGCF 128
            :..|    |||.|||||  ::| :.|||:||.:||:..||..:||..:||:....|||.......
  Fly    74 FALFTGVIPILQWLPQYSPRRD-LPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVL 137

  Fly   129 IYIFIGSSKDVPIGPTAISALLS------------------------------------------ 151
            .|:|:|:||.:.||..|::::::
  Fly   138 AYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSA 202

  Fly   152 ------------FQIAGGSW--------QIATLLTFLTGLIEILMGVFRLGFLIDFVSGPVGAGF 196
                        ||:...:.        ::||.|....|::.:||...|||.|...:|.|:..||
  Fly   203 LADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGF 267

  Fly   197 TSAVSLIIFSSQMKDFLGIKTSGNT-FLQVWISIVNDIHNISWPDFILGIVCITLLLSLRALASC 260
            |:|.:..:.::|:||.|||....:. ..::..::::.|..:...:.:....|:. :::...:.:.
  Fly   268 TTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMA-VIAFMMICNE 331

  Fly   261 TLGPKEGKTTAQKLLTGIFWTIGTARNALLVCGTAGLGYW--LFVNGKENLVKTVGFVPKGLPSF 323
            .|.|:..|.....|...:...||         ||. :..|  |:|:..   |..||.:|.|||
  Fly   332 ILKPRLSKKCRFPLPAELIMVIG---------GTL-ISKWFNLYVDYN---VNPVGKIPSGLP-- 381

  Fly   324 QPPPFHMDAVVNETTGEVLQEAQSFWDMVSTLGSGLIVVPLIALLETMAVVQAFADGKPTDATQE 388
            :|....:|.|.......:                 .|.:...:::.:|.:..|...|......||
  Fly   382 EPVLPRLDLVPKVAVDSI-----------------AIAIVTYSIIMSMGLTFAKKHGYEVRPNQE 429

  Fly   389 LIASGVCNVANSFVQGLRSNGGIARGAILNASGVRTQLSNLYTSVIVIIALLYLTPCFYYIPKAA 453
            |.|.|:.|:.......:.....::|..|.:.:|..:|:::|.::.:|::.|:::.|.|..:|:..
  Fly   430 LFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCV 494

  Fly   454 LASIIIAAV--IFMVQYRVIKPMWHSKKTDLIPGLGAFFACLVLPLQLGILVGIGINVVFILYQA 516
            ||.:||.|:  :|| |.:.:|......|.::...:..|...:::.:.:|:|:||.|:::.:..:.
  Fly   495 LAGVIIVALKPMFM-QAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKG 558

  Fly   517 ARP 519
            .:|
  Fly   559 LKP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9717	NP_651812.1	sulP	74..607	CDD:273284	117/515 (23%)
CG9717	NP_651812.1	STAS_SulP_like_sulfate_transporter	534..612	CDD:132913
Prestin	NP_649024.1	sulP	82..731	CDD:273284	117/515 (23%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	P	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
	7	6.740