DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9717 and Slc26a8

DIOPT Version :9

Sequence 1:	NP_651812.1	Gene:	CG9717 / 43636	FlyBaseID:	FBgn0039789	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_038954621.1	Gene:	Slc26a8 / 309646	RGDID:	1308898	Length:	1006	Species:	Rattus norvegicus

Alignment Length:	694	Identity:	150/694 - (21%)
Similarity:	262/694 - (37%)	Gaps:	189/694 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HTNSGFNGGSEVSLDIPTNTLYHTSRDCIVQEEQGPDESCLEGTQSCCSNLWSNIFRKKTLYKRF 73
            |...|...|   ::||...|..|                   ..|..||  |....|  .:...|
  Rat    37 HRRKGPTSG---NMDINITTFKH-------------------HVQCRCS--WHKFLR--CMLTVF 75

  Fly    74 PILVWLPQYK-KDYIFGDIVAGISVALTVIPQALAYA-----GIAGLDLQYGLYACFLGCFIYIF 132
            |.|.|:..|: ||::.||::||:||.|..:||.|..:     .|..|::   .||.|....||:.
  Rat    76 PFLEWMCLYRFKDWLLGDLLAGLSVGLVQVPQGLTLSLLTRQLIPPLNV---AYAAFCSSVIYVI 137

  Fly   133 IGSSKDVPIGP-TAISALL----------------------SFQIA------GGSWQIATLLTFL 168
            .||...:.||| ..:|||:                      .|.:.      ..|..:....|||
  Rat   138 FGSCHQMSIGPFFLVSALMINVLKERPFNNGHLIMGTFVKDDFSVPTFYLNYNRSLSMVASTTFL 202

  Fly   169 TGLIEILMGVFRLGFLIDFVSGPVGAGFTSAVSLIIFSSQMKDFLGIKTSGNTFLQVWISIVNDI 233
            ||:|::.||:..:||:..::.....:.:.:||:|.|..:||....||..|   |....|:.:.:|
  Rat   203 TGIIQLSMGMLGMGFVATYLPEAATSAYLAAVALHIILAQMTCIFGIMVS---FHAGPIAFIYNI 264

  Fly   234 HNISWPDFILGIVCITLLLSLRALASCTLGPKEGKTTAQKLLTGIF--------------WTIGT 284
            .|          .||.|             ||...|:....||.:.              :.|..
  Rat   265 IN----------YCIAL-------------PKANSTSILLFLTAVVALRVNKCIRISFNRYPIEF 306

  Fly   285 ARNALLVCGTAGLGYWLFVN----GKENLVKTVGFVPKGLPSFQPPPFHMDAVVNETTGEVLQEA 345
            ....||:     ||:.:..:    ..||....:..:|......:.|.|.:       ...::.:|
  Rat   307 PMELLLI-----LGFSMLTSRITMATENSKMLINMIPYSFVFPETPEFGI-------LSRIVLQA 359

  Fly   346 QSFWDMVSTLGSGLIVVPLIALLETMAVVQAFADGKPTDATQELIASGVCNVANSFVQGLRSNGG 410
            .|    :|.:.|.|    ||:|.:.:|.:..:.    |::.|:|||.|:||:.:||.:.....||
  Rat   360 LS----LSVVSSFL----LISLGKKIANLHNYR----TNSNQDLIAIGLCNLVSSFFRCCVFTGG 412

  Fly   411 IARGAILNASGVRTQ-----------------------------LSNLYTSV----IVIIALLYL 442
            :||..|.:.||.|.|                             ||..:.|:    ::::.::.:
  Rat   413 MARTIIQDKSGGRQQKKLACFSANRRPQLQTGTNACLTRSLQPALSPQFASLVGAGVMLLLMVKI 477

  Fly   443 TPCFYYIPKAALASIIIAAVI-FMVQYRVIKPMWHSKKTDLIPGLGAFFACLVLPLQLGILVGIG 506
            ...|..:|.|.||.||::.|: ::.....:..:|...:.:.:..:..|.|.:.|.|.:|:|:.:.
  Rat   478 GSFFDNLPNAVLAGIILSNVVPYLETIYNLPTLWRQDQYECVVWMVTFSAAIFLGLDVGLLISLV 542

  Fly   507 INVVFILYQAARPKLRIETLATTTGLKYLMLTPDRCLIFPSMEFVRKVINKQGQKSTLPVVIDC- 570
            .....|..::.|.|:.:......|.            |:.::...|:||...|.|     ::.|
  Rat   543 FTFFVITVRSHRTKILVLGQIPNTN------------IYRNVNEYREVILIPGVK-----ILQCC 590

  Fly   571 -----THIYGADFTAAKVISTMVMDFKLREQPLFFYNLQPRVAQ 609
                 .::|.......|.::.:.:..|..|....|:..:..:|:
  Rat   591 SSITFVNVYHLKHKLLKEVNMVKLPLKEEEIYALFHESETSIAE 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9717	NP_651812.1	sulP	74..607	CDD:273284	136/625 (22%)
CG9717	NP_651812.1	STAS_SulP_like_sulfate_transporter	534..612	CDD:132913	13/82 (16%)
Slc26a8	XP_038954621.1	Sulfate_transp	90..524	CDD:395733	108/486 (22%)
Slc26a8	XP_038954621.1	STAS_SulP_like_sulfate_transporter	<730..805	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920