DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9717 and SLC26A11

DIOPT Version :9

Sequence 1:	NP_651812.1	Gene:	CG9717 / 43636	FlyBaseID:	FBgn0039789	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_016879994.1	Gene:	SLC26A11 / 284129	HGNCID:	14471	Length:	696	Species:	Homo sapiens

Alignment Length:	609	Identity:	229/609 - (37%)
Similarity:	327/609 - (53%)	Gaps:	59/609 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CCSNLWSNIFRKKTLYKRFPILVWLPQYKKDYIFGDIVAGISVALTVIPQALAYAGIAGLDLQYG 119
            |||        ...|.:|.|||.|||.|...::..|.|||:||.||.||||||||.:|||..|||
Human    90 CCS--------PAALQRRLPILAWLPSYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYG 146

  Fly   120 LYACFLGCFIYIFIGSSKDVPIGPTAISALLSFQIAGGSWQIATLLTFLTGLIEILMGVFRL--- 181
            ||:.|:|||:|.|:|:|:||.:|||||.:||...........|.||.||:|.|::.|||.||
Human   147 LYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVSFYTFHEPAYAVLLAFLSGCIQLAMGVLRLAHI 211

  Fly   182 ---------------------GFLIDFVSGPVGAGFTSAVSLIIFSSQMKDFLGIKTSGNT-FLQ 224
                                 |||:||:|.||..|||||.::.|...|:|:.||::..... |||
Human   212 SPHPLGLGGAGTSSMSPLGWPGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFLQ 276

  Fly   225 VWISIVNDIHNISWPDFILGIVCITLLLSLRALASCTLGPKEGKTTAQKLLTGIFWTIGTARNAL 289
            |:.:.:. |......|.:||:||:.|||.|:.:...............:|..|:.|...||||||
Human   277 VYHTFLR-IAETRVGDAVLGLVCMLLLLVLKLMRDHVPPVHPEMPPGVRLSRGLVWAATTARNAL 340

  Fly   290 LVCGTAGLGYWLFVNGKENLVKTVGFVPKGLPSFQPPPFHMDAVVNETTGEVLQEAQSFWDMVST 354
            :|...|.:.|...|.|.:..:.| |...:|||..:.|||.    |....|.:     ||.:||..
Human   341 VVSFAALVAYSFEVTGYQPFILT-GETAEGLPPVRIPPFS----VTTANGTI-----SFTEMVQD 395

  Fly   355 LGSGLIVVPLIALLETMAVVQAFA--DGKPTDATQELIASGVCNVANSFVQGLRSNGGIARGAIL 417
            :|:||.||||:.|||::||.:|||  :....||.|||:|.|:.|:..|.|......|...|.|:.
Human   396 MGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYPVTGSFGRTAVN 460

  Fly   418 NASGVRTQLSNLYTSVIVIIALLYLTPCFYYIPKAALASIIIAAVIFMVQYRVIKPMWHSKKTDL 482
            ..|||.|....|.|.|:|:::|.|||..||||||:|||::||.||..:...::.:.:|..|:.||
Human   461 AQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDL 525

  Fly   483 IPGLGAFFACLVLPLQLGILVGIGINVVFILYQAARPKLRIETLATTTGLKYLMLTPDRCLIFPS 547
            :|....|..|. ..:|.|||.|..::::.:|:.||||:.::     :.| ..|:|.|...|.||:
Human   526 LPLCVTFLLCF-WEVQYGILAGALVSLLMLLHSAARPETKV-----SEG-PVLVLQPASGLSFPA 583

  Fly   548 MEFVRKVINKQGQKSTLP--VVIDCTHIYGADFTAAKVISTMVMDFKLREQPLFFYNLQPRVAQV 610
            ||.:|:.|..:..:.:.|  :|::|||:...|:|....:..::.||:.:...|.|..||..|.:|
Human   584 MEALREEILSRALEVSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRV 648

  Fly   611 FEGLNKDLVVIYDINTLHAKLAEK 634
            .  |:.||......:||..  |||
Human   649 L--LSADLKGFQYFSTLEE--AEK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9717	NP_651812.1	sulP	74..607	CDD:273284	214/561 (38%)
CG9717	NP_651812.1	STAS_SulP_like_sulfate_transporter	534..612	CDD:132913	25/79 (32%)
SLC26A11	XP_016879994.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141498
Domainoid	1	1.000	43	1.000	Domainoid score	I12371
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55446
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.720