DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9717 and SLC26A2

DIOPT Version :9

Sequence 1:	NP_651812.1	Gene:	CG9717 / 43636	FlyBaseID:	FBgn0039789	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_000103.2	Gene:	SLC26A2 / 1836	HGNCID:	10994	Length:	739	Species:	Homo sapiens

Alignment Length:	758	Identity:	167/758 - (22%)
Similarity:	304/758 - (40%)	Gaps:	194/758 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DSGHTNSGFNGGSEVSLDIPTNT---LYHTSRDC------IVQEEQGPD----ESCLEGTQSCCS 57
            ||...|..:..|..:.|...::|   .:.|:..|      :::.::..|    |..::..|..|.
Human    15 DSAEGNDSYPSGIHLELQRESSTDFKQFETNDQCRPYHRILIERQEKSDTNFKEFVIKKLQKNCQ 79

  Fly    58 NLWSNIFRKKTLYKRFPILVWLPQYK-KDYIFGDIVAGISVALTVIPQALAYAGIAGLDLQYGLY 121
              .|....|..:....|:|.|||:|. |..|.||:::|:.|.:.::||::||:.:||.:..||||
Human    80 --CSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLY 142

  Fly   122 ACFLGCFIYIFIGSSKDVPIGPTAISALL-------SFQIAG---------------GSW----- 159
            ..|....||..:|:|:.:.:|...:..|:       ..|.||               ||.
Human   143 TSFFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHT 207

  Fly   160 ------------QIATLLTFLTGLIEILMGVFRLGFLIDFVSGPVGAGFTSAVSLIIFSSQMKDF 212
                        .:.:.:||:.|:.::.||.|::||:..::|..:.:||.:..|..|.:||.|..
Human   208 SDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYL 272

  Fly   213 LGI---KTSG-NTFLQVWISIVNDIHNISWPDFILGIVCITLLLSLRALASCTLGPKEGKTTAQK 273
            ||:   :|:| .:.:..||.:..:||..:..|.|..::|:.:||..:.|         .:....|
Human   273 LGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKEL---------NEHFKSK 328

  Fly   274 LLTGIFWTIGTARNALLVCGTAGLGYWLFVNGK--ENLVKTV-GFVPKGLPSFQPPPFHMDAVVN 335
            |...|     .....::|..|....:     ||  ||...:: |.:|.|   |.||.      |.
Human   329 LKAPI-----PIELVVVVAATLASHF-----GKLHENYNSSIAGHIPTG---FMPPK------VP 374

  Fly   336 ETTGEVLQEAQSFWDMVSTLGSGLIVVPLIALLETMAVVQAFA--DGKPTDATQELIASGVCNVA 398
            |            |:::.::....|.:.:|....|:::.:.||  .|....|.||:.|.|.||:.
Human   375 E------------WNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNII 427

  Fly   399 NSFVQGLRSNGGIARGAILNASGVRTQLSNLYTSVIVIIALLYLTPCFYYIPKAALASIIIAAVI 463
            .||.....::..:|:..:..::|..||||.:.|::::::.||.:.|.||.:.|:.|..|.|..:.
Human   428 PSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLR 492

  Fly   464 -FMVQYRVIKPMWHSKKTDLIPGLGAFFACLVLPLQLGILVGIGINVVFILYQAARPKLRI---- 523
             .:.::|.:..||...:.|.:.......:..:|..::|:|||:..::..::.:..:||..:
Human   493 GALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLV 557

  Fly   524 ---ETLATTTGLKYLMLTPDRCLIFPSMEFVRKV--INKQGQKSTL------------------- 564
               |...:.:..|.|.:.|. ..||   .||..:  |||:..||.|
Human   558 EESEVFESVSAYKNLQIKPG-IKIF---RFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAK 618

  Fly   565 -----------------------------PVVIDCTHIYGADFTAAKVISTMVMDF--------- 591
                                         .:||||:.|...|......:..:..|:
Human   619 RKIKEKVVTLGGIQDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLL 683

  Fly   592 -----------------KLREQPLFFYNLQPRVAQVFEGLNKD 617
                             |..|:.|.||::..  |..|..::|:
Human   684 AQCNPTVRDSLTNGEYCKKEEENLLFYSVYE--AMAFAEVSKN 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9717	NP_651812.1	sulP	74..607	CDD:273284	150/665 (23%)
CG9717	NP_651812.1	STAS_SulP_like_sulfate_transporter	534..612	CDD:132913	25/153 (16%)
SLC26A2	NP_000103.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		3/11 (27%)
		sulP	94..715	CDD:273284	150/666 (23%)
		STAS	570..707	CDD:132911	22/140 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810