Protein Alignment CG9717 and SLC26A8

DIOPT Version :10

• Sequence 1: NP_651812.1
• Gene: CG9717 / 43636
• FlyBaseID: FBgn0039789
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_443193.1
• Gene: SLC26A8 / 116369
• HGNCID: 14468
• Length: 970
• Species: Homo sapiens
• Alignment Length: 718
• Identity: 169/718 - (23%)
• Similarity: 280/718 - (38%)
• Gaps: 185/718 - (25%)

  Fly    12 SGFNGGSEVSLDIPTNTLYHTSRDCIVQEEQGPDESCLEGTQSCCSNLWSNIFRK---------- 66
            |||:..|.     ..:..|...|: :..||....|...:.:.|...|:....||.
Human    10 SGFSSKSR-----RNSFAYDVKRE-VYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHR 68

  Fly    67 --KTLYKRFPILVWLPQYK-KDYIFGDIVAGISVALTVIPQALAYAGIA-----GLDLQYGLYAC 123
              :.:...||.|.|:..|: ||::.||::|||||.|..:||.|..:.:|     .|::   .||.
Human    69 FLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNI---AYAA 130

  Fly   124 FLGCFIYIFIGSSKDVPIGP-TAISALL----------SFQIAGGSW------------------ 159
            |....||:..||...:.||. ..:||||          :.|:..||:
Human   131 FCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSL 195

  Fly   160 QIATLLTFLTGLIEILMGVFRLGFLIDFVSGPVGAGFTSAVSLIIFSSQMKDFLGIKTSGNTFLQ 224
            .:....|||||:|:::|||..|||:..::.....:.:.:||:|.|..||:....||..|   |..
Human   196 SVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMIS---FHA 257

  Fly   225 VWISIVNDIHNISWPDFILGIVCITLLLSLRALASCTLGPKEGKTTAQKLLTGIFWTIGTARNAL 289
            ..||...||.|          .|:.|             ||...|:....||.:.        ||
Human   258 GPISFFYDIIN----------YCVAL-------------PKANSTSILVFLTVVV--------AL 291

  Fly   290 LVCGTAGLGYWLF-VNGKENLVKTVGFVPKGLPSFQPPPFHMDAVVNETTGEVLQEAQSFWDMV- 352
            .:.....:.:..: :.....|...:||                .|:........:.:|:..||:
Human   292 RINKCIRISFNQYPIEFPMELFLIIGF----------------TVIANKISMATETSQTLIDMIP 340

  Fly   353 -STLGSGLIVVPLIALLETMAVVQAFA-----------DGK--------PTDATQELIASGVCNV 397
             |.|   |.|.|..:||..: ::|||:           .||        ..::.|:|||.|:|||
Human   341 YSFL---LPVTPDFSLLPKI-ILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNV 401

  Fly   398 ANSFVQGLRSNGGIARGAILNASGVRTQLSNLYTSVIVIIALLYLTPCFYYIPKAALASIIIAAV 462
            .:||.:.....|.|||..|.:.||.|.|.::|..:.::::.::.:...||.:|.|.||.||::.|
Human   402 VSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNV 466

  Fly   463 I-FMVQYRVIKPMWHSKKTDLIPGLGAFFACLVLPLQLGILVGIGINVVFILYQAARPKLRIETL 526
            | ::.....:..:|...:.|....:..|.:.:.|.|.:|:::.: ::..||            |.
Human   467 IPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISV-VSAFFI------------TT 518

  Fly   527 ATTTGLKYLML--TPDRCLIFPSMEFVRKVINKQGQKSTLPVVIDC------THIYGADFTAAKV 583
            ..:...|.|:|  .|: ..|:.|:...|::|...|.|     :..|      .::|.......|.
Human   519 VRSHRAKILLLGQIPN-TNIYRSINDYREIITIPGVK-----IFQCCSSITFVNVYYLKHKLLKE 577

  Fly   584 ISTMVMDFKLREQPLFFY------NLQ-----------------PRVAQVFEGLNKDLVVIYDIN 625
            :.  ::...|:|:.:|..      |||                 ||:.......||.......||
Human   578 VD--MVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSIN 640

  Fly   626 TLH 628
            .:|
Human   641 LIH 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9717	NP_651812.1	SUL1	82..612	CDD:440424	147/618 (24%)
SLC26A8	NP_443193.1	PRK11660	78..584	CDD:481320	142/583 (24%)
		Interaction with RACGAP1. /evidence=ECO:0000269|PubMed:11278976	664..970
		STAS_SulP_like_sulfate_transporter	<719..776	CDD:132913
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	858..970
		Trypan_PARP	<873..923	CDD:368653