DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9702 and SLC26A4

DIOPT Version :9

Sequence 1:	NP_001263113.1	Gene:	CG9702 / 43634	FlyBaseID:	FBgn0039787	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_000432.1	Gene:	SLC26A4 / 5172	HGNCID:	8818	Length:	780	Species:	Homo sapiens

Alignment Length:	750	Identity:	171/750 - (22%)
Similarity:	298/750 - (39%)	Gaps:	209/750 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NEVTFRKQAEVNQNLEAQFDSSSTDFILITDHRTSKSKSLEQLEASKESKNPESCCSRYARNIFR 70
            :|:.|::|.|                     .|..:.|:|.:..|        .|||...:..|.
Human    28 SELAFQQQHE---------------------RRLQERKTLRESLA--------KCCSCSRKRAFG 63

  Fly    71 -KKTLLKRLPFLTWLPHYN-RQDCIGDLIAGFTVGLTVIPQGLAYSGVVGLPPEYGLYGSFMGCF 133
             .|||   :|.|.|||.|. ::..:.|:|:|.:.||....||:||:.:..:|..||||.:|....
Human    64 VLKTL---VPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPIL 125

  Fly   134 VYVLLGTCKDSTIGSTAVASLMT----------FQFAQGSWQRSVL------------------- 169
            .|.:.||.:..::|...|.|||.          ..|...|...:||
Human   126 TYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIAS 190

  Fly   170 -LTFLTGIIEILMAIFKLGCLVEFVSGPVSAGFTSAVALIVSTSQMRSMLGV--KSDGG--SFLA 229
             ||.|.|||:::....::|.:|.:::.|:..|||:|.|..|..||::.:|.|  |:..|  |.:.
Human   191 ALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIY 255

  Fly   230 TWISMFRDIENVRVADTCLGFGCVILLLAMRSLGKFTIGPKDESRRNGFQRVVNTVIKFLSTSRN 294
            |.:.:|::|.:..:||...|...:::.:|::.|            .:.|:..:...|..     .
Human   256 TLVEIFQNIGDTNLADFTAGLLTIVVCMAVKEL------------NDRFRHKIPVPIPI-----E 303

  Fly   295 ASVVILFTAVTMYLDANGTNPFRLTGNIPKGMPTPSLPPFSIEPQPGNETAGIPAVEGQTFPEMV 359
            ..|.|:.||::...:........:..:||:|...|.|||.|:                  |.||:
Human   304 VIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSL------------------FSEML 350

  Fly   360 QSLGYGLVIVPLMALLETMSVCKAFAK--GKQIDITQEMIACGVGNIATSLFSGYRCNGGLARSA 422
             :..:.:.:|   |....:||.|.:|.  ...||..||.||.|:.||.:..||.:.....|:|:|
Human   351 -AASFSIAVV---AYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTA 411

  Fly   423 VNNASGCRTNMSNLYIGVIVVLALNFLTEYIAFIPKAVLAAIIISAV--IFQVQYQVVTPMWRSK 485
            |..::|.:|.::.:....||::|:..|.:.:..:.|:||||::|:.:  :| :|...:..:||..
Human   412 VQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMF-MQLCDIPRLWRQN 475

  Fly   486 RSDLVPGILAFVTCLVLPLEIGIMVAIGVNLLFILYYAARP--------------KVT--LEQLE 534
            :.|.|..:...:..::|.|::|::..:...||.::.....|              |.|  .:.:|
Human   476 KIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIE 540

  Fly   535 TQQGIRFVKITP----------DRCLIFPSVEF----VRNMVLKLGSK----------------- 568
            ..||::.::.:.          .:| |..:|.|    |.|..||...|
Human   541 EPQGVKILRFSSPIFYGNVDGFKKC-IKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGI 604

  Fly   569 -------------------------------------STLPV------------VIDCTYIYAAD 584
                                                 |.|||            |:||..|...|
Human   605 ISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLD 669

  Fly   585 FTAAKVISSIVDDFRRRQQKIIFFNLKPSVVSVFE 619
            ....:.:..||.:|:|....:.|.:|:..|:...|
Human   670 VVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLE 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9702	NP_001263113.1	SUL1	72..614	CDD:223732	157/676 (23%)
CG9702	NP_001263113.1	STAS_SulP_like_sulfate_transporter	531..619	CDD:132913	28/167 (17%)
SLC26A4	NP_000432.1	sulP	70..725	CDD:273284	155/675 (23%)
		STAS_SulP_like_sulfate_transporter	536..722	CDD:132913	28/169 (17%)
		Snf7	<583..654	CDD:304451	6/70 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910