DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9702 and SLC26A8

DIOPT Version :9

Sequence 1:	NP_001263113.1	Gene:	CG9702 / 43634	FlyBaseID:	FBgn0039787	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001180405.1	Gene:	SLC26A8 / 116369	HGNCID:	14468	Length:	970	Species:	Homo sapiens

Alignment Length:	745	Identity:	172/745 - (23%)
Similarity:	292/745 - (39%)	Gaps:	183/745 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NEVTFRKQAEVNQNLEAQFDSSSTDFILITDHRTSKSKSLEQLEASKESKNPESCCS--RYARNI 68
            ||.||:      |..:.:..||....|.||..|                .:.:..||  |:.|
Human    31 NEETFQ------QEHKRKASSSGNMNINITTFR----------------HHVQCRCSWHRFLR-- 71

  Fly    69 FRKKTLLKRLPFLTWLPHYNRQD-CIGDLIAGFTVGLTVIPQGLAYSGVVG--LPPEYGLYGSFM 130
                .:|...|||.|:..|..:| .:|||:||.:|||..:||||..|.:..  :||....|.:|.
Human    72 ----CVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFC 132

  Fly   131 GCFVYVLLGTCKDSTIGSTAVASLMTF-----------QFAQGSWQR------SVLL-------- 170
            ...:||:.|:|...:|||..:.|.:..           |...||:.:      |.|:
Human   133 SSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSV 197

  Fly   171 ----TFLTGIIEILMAIFKLGCLVEFVSGPVSAGFTSAVALIVSTSQMRSMLGVKSDGGSFLATW 231
                |||||||:::|.:..||.:..::.....:.:.:||||.:..||:..:.|:..   ||.|..
Human   198 VATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMI---SFHAGP 259

  Fly   232 ISMFRDIENVRVA------DTCLGFGCVILLLAMR-----SLGKFTIG-PKDESRRNGFQRVVNT 284
            ||.|.||.|..||      .:.|.|..|::.|.:.     |..::.|. |.:.....||..:.|.
Human   260 ISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANK 324

  Fly   285 VIKFLSTSRNASVVILFTAVTMYLDANGTNPFRLTGNIPKGMPTPSLPPFSIEPQPGNETAGIPA 349
            :.....||:        |.:.|               ||.....|..|.||:.|:
Human   325 ISMATETSQ--------TLIDM---------------IPYSFLLPVTPDFSLLPK---------- 356

  Fly   350 VEGQTFPEMVQSLGYGLVIVPLMALLETMSVCKAFAKGKQI--------DITQEMIACGVGNIAT 406
                   .::|:....||...|:..|           ||:|        :..|::||.|:.|:.:
Human   357 -------IILQAFSLSLVSSFLLIFL-----------GKKIASLHNYSVNSNQDLIAIGLCNVVS 403

  Fly   407 SLFSGYRCNGGLARSAVNNASGCRTNMSNLYIGVIVVLALNFLTEYIAFIPKAVLAAIIISAVIF 471
            |.|......|.:||:.:.:.||.|...::|....:::|.:..:..:...:|.||||.||:|.||.
Human   404 SFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIP 468

  Fly   472 QVQYQVVTP-MWRSKRSDLVPGILAFVTCLVLPLEIGIMVAIGVNLLFILYYAA-RPKVTL---- 530
            .::.....| :||..:.|....::.|.:.:.|.|:||::::: |:..||....: |.|:.|
Human   469 YLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISV-VSAFFITTVRSHRAKILLLGQI 532

  Fly   531 ------------EQLETQQGIRFVKITPDRCLIFPSVEFVRNMVLKLGSKSTLPV----VIDCTY 579
                        .::.|..|::..:....  :.|.:|.::::.:||......:|:    :.....
Human   533 PNTNIYRSINDYREIITIPGVKIFQCCSS--ITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFN 595

  Fly   580 IYAADFTAAKVISSI--VDDF---------RRRQQKIIFFNLKPSVVSVFEGLNTRLVLCYNTHA 633
            ....:....|:....  .||.         .|.:.|     |.|...|:      .|:.|.:..:
Human   596 SSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENK-----LDPEASSI------NLIHCSHFES 649

  Fly   634 LNQELRPDEPDLSRSVDSLDHAESGNGTSE 663
            :|......|..:..:|.|:.....|....|
Human   650 MNTSQTASEDQVPYTVSSVSQKNQGQQYEE 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9702	NP_001263113.1	SUL1	72..614	CDD:223732	148/626 (24%)
CG9702	NP_001263113.1	STAS_SulP_like_sulfate_transporter	531..619	CDD:132913	15/102 (15%)
SLC26A8	NP_001180405.1	Sulfate_transp	92..493	CDD:279284	116/454 (26%)
		STAS	544..>584	CDD:294402	6/41 (15%)
		Interaction with RACGAP1. /evidence=ECO:0000269\|PubMed:11278976	664..970		4/16 (25%)
		STAS_SulP_like_sulfate_transporter	<719..776	CDD:132913
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	858..970
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820