DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9702 and SLC26A9

DIOPT Version :9

Sequence 1:	NP_001263113.1	Gene:	CG9702 / 43634	FlyBaseID:	FBgn0039787	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_599152.2	Gene:	SLC26A9 / 115019	HGNCID:	14469	Length:	887	Species:	Homo sapiens

Alignment Length:	682	Identity:	159/682 - (23%)
Similarity:	273/682 - (40%)	Gaps:	139/682 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SLEQLEASKESKNPESCCSRYARNIFR------KKTLLKRLPFLTWLPHYNRQD-CIGDLIAGFT 101
            ||...:...|.|:.........||.||      |..:...||.|:|||.|..:| .|.||:.|.:
Human    16 SLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLS 80

  Fly   102 VGLTVIPQGLAYSGVVGLPPEYGLYGSFMGCFVYVLLGTCKDSTIGSTAVASLMT---------- 156
            .|...:|||:|::.:..||...|||.||.....|..||.......|:.||.|::.
Human    81 GGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPE 145

  Fly   157 --FQFAQGSWQRSVL---------------LTFLTGIIEILMAIFKLGCLVEFVSGPVSAGFTSA 204
              ||....:...|.:               |..||.||::.:...:.|.:..::|.....||.:|
Human   146 SKFQVFNNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTA 210

  Fly   205 VALIVSTSQMRSMLGVK----SDGGSFLATWISMFRDIENVRVADTCLGFGCVILLLAMRSLGKF 265
            ..|.:..|.::.:.|:.    :..||.:.|:|.:.:::.:..:|.         |:.|:.| |.|
Human   211 AGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIAS---------LIFALIS-GAF 265

  Fly   266 TIGPKDESRRNGFQRVVNTVIKFLSTSRNASVVILFTAVTMYLDANGTNPFRLTGNIPKGMPTPS 330
            .:..|:.:.|...:      |:| .......||::.||::...........::.|.|.:|.|||.
Human   266 LVLVKELNARYMHK------IRF-PIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPV 323

  Fly   331 LPPFSIEPQPGNETAGIPAVEGQTFPEMVQSLGYGLVIVPLMALLETMSVCKAFAKGKQIDITQE 395
            .|..|                  .:.:|: ...:.|.||..:..| .|....|...|..:|..||
Human   324 SPVVS------------------QWKDMI-GTAFSLAIVSYVINL-AMGRTLANKHGYDVDSNQE 368

  Fly   396 MIACGVGNIATSLFSGYRCNGGLARSAVNNASGCRTNMSNLYIGVIVVLALNFLTEYIAFIPKAV 460
            |||.|..|...|.|..:.....|:.:...:.:|.::.:::|.:.::|::.:..|..|:..:||:|
Human   369 MIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSV 433

  Fly   461 LAAIIISAVIFQVQYQVVTP---MWRSKRSDLVPGILAFVTCLVLPLEIGIMVAIGVNLLFILY- 521
            |.|:|  ||..:...:.:|.   :||..:.|....:::|::...|.|..|:.|.:..::|.:::
Human   434 LGALI--AVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQ 496

  Fly   522 ------YA----------ARPKVTLEQLETQQGIRFVKITPDRCLIFPSVEFVRNMVL-KLGSKS 569
                  ||          ..|| |..:.:..|||:.  ||....|.|.:.|..|..|: |.|...
Human   497 TQFRNGYALAQVMDTDIYVNPK-TYNRAQDIQGIKI--ITYCSPLYFANSEIFRQKVIAKTGMDP 558

  Fly   570 TLPVVIDCTYIYAADFTAAKVISSIVDDFRRR----QQKIIFFNLKPSVVSVFEGLNTRLVLCYN 630
            ...::....|:...:              :||    ||:...| :|...||:
Human   559 QKVLLAKQKYLKKQE--------------KRRMRPTQQRRSLF-MKTKTVSL------------- 595

  Fly   631 THALNQELRPDEPDLSRSVDSLDHAESGNGTS 662
                 |||:.|..: :...|..::....||||
Human   596 -----QELQQDFEN-APPTDPNNNQTPANGTS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9702	NP_001263113.1	SUL1	72..614	CDD:223732	139/598 (23%)
CG9702	NP_001263113.1	STAS_SulP_like_sulfate_transporter	531..619	CDD:132913	21/92 (23%)
SLC26A9	NP_599152.2	Sulfate_transp	74..468	CDD:279284	100/432 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..650		5/21 (24%)
		STAS_SulP_like_sulfate_transporter	<662..730	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810