DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and lmod1b

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_001335496.4	Gene:	lmod1b / 795335	ZFINID:	ZDB-GENE-141215-22	Length:	671	Species:	Danio rerio

Alignment Length:	531	Identity:	120/531 - (22%)
Similarity:	214/531 - (40%)	Gaps:	127/531 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDIEDVFGG----SAEETKPEPDA--QSKTSVVTEHT--EEVIPGETEKMVTETIDEDGDVVEET 58
            ||..|  ||    |:..:.|:.|.  :.:|..|||.|  |:..|....|. .|.|::..| .::.
Zfish   117 SDSRD--GGLQRTSSTSSFPKRDGRLEDRTRRVTEGTRDEKFGPSAVSKR-DEEIEKKND-TKDQ 177

  Fly    59 TEVTRKTVKRTMKITETSATTKTTTLTTPAKLYGKDLSEYDD--------VDVESLLAQLSPEE- 114
            .:.:|...:|.|:.:.:|.|.:..:.....|...|:.::.:|        ...:.:::::..:|
Zfish   178 NDGSRLRDRREMRESSSSKTKELISKLQEKKEDSKEKNKKEDRGKRESGESRAKEMISRIQEKEE 242

  Fly   115 ------ITILAKEVDPDDNFLPPDQRNSYEC----TKEATGPLNRKQ------------LIEHIN 157
                  ..|..:|......:|...:.|..:.    |||.....:.||            |.|:..
Zfish   243 KEREKKEEIRKREETKSKGYLSRLEENQNQVHEDKTKEENKHRDEKQIRSSEKVKETTALSENKE 307

  Fly   158 KQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEEIIDLA 222
            |::.......|.......|.||           |::...:...::.:..|..:.:...:.|:
Zfish   308 KESENVKRLQECNAKSSDKGRG-----------DVQKHNENVNEVHKPKEEKIENCVSDTIL--- 358

  Fly   223 AILGFHSMMNQDQYHASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEESIKRVKDDDSKL 287
                                ||:         ||..::     |..:.:..:|.:::|:.:|..:
Zfish   359 --------------------KGK---------TKEEEE-----DDESASMFDEDLEKVRRNDPGM 389

  Fly   288 IDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRVLNVETN 352
            .|||:||.:.|..:.|.|...||..|.|::..||.|....|..|..:|..:..:|::..:|:::|
Zfish   390 TDLNVNNSEVIKTKTLIQFSEALKNNTHIKAFSLANCRADDHVAYAIADTLRNNKSITSINLDSN 454

  Fly   353 FISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLEFNDARH 417
            .::...|:.|:|||....|:.|.|..|||. ::|.|.|||:|.::::|::||:||.|.|....|.
Zfish   455 LLTSKGIMSLIQALQHNSTLTELRFHNQRH-IIGGKSEMEMTKILKENTTLLKLGYHFELAGPRM 518

  Fly   418 RVAAHLQRNIDRIFRVQKL---------------------KPNLPKLILPGNMEIERDLVAYNRS 461
            .:...|.||:|| .|.::|                     ||:..|    |:.         ..|
Zfish   519 TMTNILSRNMDR-QRQKRLQEQKQAQAQGAGDKKDSLGVPKPSFGK----GSP---------RAS 569

  Fly   462 ATPSPSPSPQP 472
            ..|||.|||.|
Zfish   570 PIPSPIPSPAP 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	22/172 (13%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	46/135 (34%)
lmod1b	XP_001335496.4	Neuromodulin_N	<90..>348	CDD:331332	46/245 (19%)
lmod1b	XP_001335496.4	LRR_RI	<410..508	CDD:330982	33/98 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.810