DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and TMOD1

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001159588.1	Gene:	TMOD1 / 7111	HGNCID:	11871	Length:	359	Species:	Homo sapiens

Alignment Length:	364	Identity:	135/364 - (37%)
Similarity:	214/364 - (58%)	Gaps:	24/364 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITILAK---EVDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            |.::|.:|.|:|.:.:|..|:.||:..|..   |:|||:..||...|...:.||..|||..|::|
Human     3 YRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREEL 67

  Fly   153 IEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEE 217
            ::|:.|||.|..|:.:..|:. |:.|||.|||..:....:  .|.:.::  .|.|.||.:|:..|
Human    68 LDHLEKQAKEFKDREDLVPYT-GEKRGKVWVPKQKPLDPV--LESVTLE--PELEEALANASDAE 127

  Fly   218 IIDLAAILGFHSMMNQDQYH-----ASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEESI 277
            :.|:|||||.|::|:..||:     :|::||.     |.:.:.|.||.|..|.:.||:|||||::
Human   128 LCDIAAILGMHTLMSNQQYYQALSSSSIMNKE-----GLNSVIKPTQYKPVPDEEPNSTDVEETL 187

  Fly   278 KRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSK 342
            :|:|::|.||.::|||||:||....|:....||.:|.:::..|:......|..|..||..::::|
Human   188 ERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENK 252

  Fly   343 TLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLG 407
            .|:.||||:||||...|::||:||....::.|.:..|| |..||||:||||..::|||::||:.|
Human   253 VLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQ-SQPLGNKVEMEIVSMLEKNATLLKFG 316

  Fly   408 LHLEFNDARHRVAAHLQRNIDRIFRVQKLK----PNLPK 442
            .|......|.|.:..:..|.| :.|.::|.    |.:||
Human   317 YHFTQQGPRLRASNAMMNNND-LVRKRRLADLTGPIIPK 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	53/144 (37%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	54/135 (40%)
TMOD1	NP_001159588.1	Tropomodulin	3..143	CDD:281268	53/144 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..61		10/24 (42%)
		Tropomyosin-binding. /evidence=ECO:0000255	39..138		39/103 (38%)
		LRR_RI	<191..>314	CDD:238064	51/123 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157767
Domainoid	1	1.000	134	1.000	Domainoid score	I5012
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20701
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3507
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47963
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	1	1.000	-	-		FOG0001180
OrthoInspector	1	1.000	-	-		otm40482
orthoMCL	1	0.900	-	-		OOG6_105629
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2851
SonicParanoid	1	1.000	-	-		X804
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840