DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and lmod2b

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_005164550.1	Gene:	lmod2b / 664708	ZFINID:	ZDB-GENE-041210-356	Length:	596	Species:	Danio rerio

Alignment Length:	495	Identity:	131/495 - (26%)
Similarity:	216/495 - (43%)	Gaps:	112/495 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RTMKITETSATTKTTTLTTPAKLYG--KDLSEYDDVDVESLLAQLSPEEITILAKE---VDPDDN 127
            ||:|.::.....:..........:|  ::||:|:|:|.:.|||.|:.||:..|.||   :|||||
Zfish    14 RTLKTSDAPTLRQNQDYQEAMSTFGYRRELSKYEDLDEDELLASLTAEELQELEKELADIDPDDN 78

  Fly   128 FLPPDQRNSYECTKEATGPLNRKQLIEH--------INKQAI----------------------E 162
             ||...|...:..|..||..:|:.|:::        :.::.|                      :
Zfish    79 -LPIGLRQRDQTAKTPTGTFSREALMKYWENETRKLLEEERIGSTSPGEKDKDSREEEECVTESD 142

  Fly   163 TPDQPEFEPFVQGKVRGKKWVPPPRDA-------RDIEAEEQIAIDMGEEYEHALNDATQEE--- 217
            |.|..:.:..|:   ..:|.....|:|       .:.||:|.:..:..||.|...:|..::|
Zfish   143 TEDSGDEKDEVE---ESEKDTEKYREAEEDREEEEESEADEPVTEEEEEEEEEEEDDKEEQEEQK 204

  Fly   218 IIDLAAILGFHSM-MNQDQYHASLLNKGQPVGLGWDGITKSTQQ-----KLFPMDP----PNNTD 272
            .||....:| ||| .|....|.            |...::|.|:     |....:|    .|.|.
Zfish   205 EIDNHPKMG-HSMECNTQPQHC------------WSSNSQSNQRQIGEPKAQSQEPGRTSGNPTV 256

  Fly   273 VEESIKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAA 337
            .:|.:::|.::|.:..::|||||.|||.:.|.:...||..|..:.|.||.|....|:.|..:|..
Zfish   257 ADEVLEKVLNNDPETTEVNLNNIDNISQDTLIRFAEALRSNAQVRVFSLANTHADDQVAFAIAKM 321

  Fly   338 IEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSS 402
            :.:::.:..||:|:|||:...|:.||||:.:.:|:.|.|..|||. :.|.::||||..|:.:|::
Zfish   322 LRENRNITNLNIESNFITGKGILALVQAITQNNTLTEMRFHNQRH-ICGGQVEMEIVKLLRENTT 385

  Fly   403 LLRLGLHLEFNDARHRVAAHLQRNID--RIFRVQKLK--------PNLPKLI------------- 444
            |::||...:....|..:...|.||.|  |..|:|:|:        |..|:.:
Zfish   386 LIKLGYQFDLPGPRISMTTLLTRNQDLQRQKRMQELRLQNGGTATPTNPRTVALQKSTSTSSPHS 450

  Fly   445 -----------LPGNMEIERDLVAYNRSATPSPSPSPQPP 473
                       ||     ..|:...|....|.|.|.|.||
Zfish   451 SPRSSPWSSPKLP-----HVDMAKKNAPPAPPPPPPPPPP 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	49/187 (26%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	47/135 (35%)
lmod2b	XP_005164550.1	Tropomodulin	39..161	CDD:281268	32/125 (26%)
lmod2b	XP_005164550.1	LRR_RI	<259..427	CDD:238064	58/168 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020