DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and Lrrc74a

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001182696.1	Gene:	Lrrc74a / 627607	MGIID:	3646959	Length:	487	Species:	Mus musculus

Alignment Length:	473	Identity:	91/473 - (19%)
Similarity:	165/473 - (34%)	Gaps:	129/473 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 VDPDDNFLPPDQRNSYECTKEATGPLNRKQLIEHINKQAIE---TPDQPEFEPFVQGKVRGKKWV 183
            :|.|||                       :.:|...|...|   ||...:...:.:.:|...  |
Mouse     1 MDDDDN-----------------------EPVESETKDEAEAELTPQDSDVTLYCEAEVLPS--V 40

  Fly   184 PPPRDARDIEAEEQIAIDMGEEYEHALNDATQEEIIDLAAILGF----HSMMNQDQYHASLLNKG 244
            ...:.||: ::|..:.|   |:.|...|...:|..::...::|.    :.:.|.::...:|.:.|
Mouse    41 EKEKSARE-DSETDLEI---EDTEKFFNIGQKELYLEACKLVGVVPASYFIRNMEESCVNLNHHG 101

  Fly   245 -QPVGLGWDGITKSTQQKLFPMDPPNNTDVEESIKRVKD---DDSKLIDLNL--NN--------I 295
             .|:|.....||..:...:..::..:|...||.|..:.:   ::..|.:||:  ||        |
Mouse   102 LGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARII 166

  Fly   296 KNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRVLNVETNFISPPVIV 360
            .|...|          .|..|..|.|:.....::.|.||..|:..:..:|.||:..|..|.....
Mouse   167 SNFLQE----------NNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGE 221

  Fly   361 KLVQALLKCHTIEEFRAS----NQRSAV---------------------LGNKIEMEITDLVEKN 400
            .|.|.|.....::....|    |.|.||                     .||:..:.:.|.:..|
Mouse   222 HLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGALALGDALRLN 286

  Fly   401 SSLLRLGLHLEFNDARHRVAAHLQRNIDRIFRVQKLKPNLPKLILPGNMEIERDLVAYNRSATPS 465
            |.|:.  :.:..|...:..|:.:.:.::....:|.||..|..|.|.|         ||:
Mouse   287 SCLVY--VDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEG---------AYS------ 334

  Fly   466 PSPSPQPPVDYEVEEDPDNMVIRGGGDAFDPDVDPDNM--------VVPGSRSVTPNYD--DEGV 520
                    :...::.:|.:.:         .|:|..|:        |:.|..::.|..|  .:|:
Mouse   335 --------LIMAIKRNPKSRM---------EDIDISNVLVSEQFVKVLDGVCAIHPQLDVVYKGL 382

  Fly   521 YQAHTWTSASHGPSDQEL 538
            ....|..|.|.|.:...|
Mouse   383 QGLSTKKSISLGTNPMRL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	20/117 (17%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	36/170 (21%)
Lrrc74a	NP_001182696.1	LRR_RI	73..333	CDD:393385	56/280 (20%)
		leucine-rich repeat	148..176	CDD:275380	9/37 (24%)
		leucine-rich repeat	177..204	CDD:275380	7/26 (27%)
		leucine-rich repeat	205..232	CDD:275380	8/26 (31%)
		leucine-rich repeat	233..257	CDD:275380	5/23 (22%)
		leucine-rich repeat	261..284	CDD:275380	3/22 (14%)
		leucine-rich repeat	285..313	CDD:275380	5/29 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910