DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and Tmod2

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001033799.1	Gene:	Tmod2 / 50876	MGIID:	1355335	Length:	351	Species:	Mus musculus

Alignment Length:	347	Identity:	122/347 - (35%)
Similarity:	196/347 - (56%)	Gaps:	17/347 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITILAK---EVDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            :.|.|.:|.::|.:.||.:||.||:..|..   ::||:...||...|...:..|.||||.:|:.|
Mouse     5 FQKGLEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESATLPAGFRQKDQTQKAATGPFDREHL 69

  Fly   153 IEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEE 217
            :.::.|:|:|..|:.:|.||. |:.:|:.::|..:.. :...||::.:|  .|.|.||..|:..|
Mouse    70 LMYLEKEALEQKDREDFVPFT-GEKKGRVFIPKEKPV-ETRKEEKVTLD--PELEEALASASDTE 130

  Fly   218 IIDLAAILGFHSMMNQDQYHASLLNKGQPVGLGWDG----ITKSTQQKLFPMDPPNNTDVEESIK 278
            :.||||:||.|:::|..::.....|     |.|..|    :.|..:.|....:|||.|:||.|::
Mouse   131 LYDLAAVLGVHNLLNNPKFDEETTN-----GEGRKGPVRNVVKGEKAKPVFEEPPNPTNVEASLQ 190

  Fly   279 RVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKT 343
            ::|.:|..|.::||||||||....|::...:|..|.|::..||......|..||..|..::.:||
Mouse   191 QMKANDPSLQEVNLNNIKNIPIPTLKEFAKSLETNTHVKKFSLAATRSNDPVALAFAEMLKVNKT 255

  Fly   344 LRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGL 408
            |:.||||:|||:...|:.||:||.:..|:.|.:..|||.. ||..:||||..::|:||.:|:.|.
Mouse   256 LKSLNVESNFITGTGILALVEALRENDTLTEIKIDNQRQQ-LGTAVEMEIAQMLEENSRILKFGY 319

  Fly   409 HLEFNDARHRVAAHLQRNIDRI 430
            .......|.||||.:.:|.|.:
Mouse   320 QFTKQGPRTRVAAAITKNNDLV 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	49/144 (34%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	53/135 (39%)
Tmod2	NP_001033799.1	Tropomodulin	5..146	CDD:397382	49/144 (34%)
Tmod2	NP_001033799.1	LRR_RI	<215..323	CDD:423007	41/108 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848157
Domainoid	1	1.000	131	1.000	Domainoid score	I5112
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3508
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47963
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	1	1.000	-	-		FOG0001180
OrthoInspector	1	1.000	-	-		otm42558
orthoMCL	1	0.900	-	-		OOG6_105629
Panther	1	1.100	-	-	LDO	PTHR10901
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2851
SonicParanoid	1	1.000	-	-		X804
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840