DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and Tmod4

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_057921.1	Gene:	Tmod4 / 50874	MGIID:	1355285	Length:	345	Species:	Mus musculus

Alignment Length:	349	Identity:	118/349 - (33%)
Similarity:	205/349 - (58%)	Gaps:	13/349 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITIL---AKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            |.|:|.:|.|:|.:.:|..|||||:..|   .:|:||::..||...|...:..|..||||:|..|
Mouse     4 YQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDRDAL 68

  Fly   153 IEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEE 217
            ::::.:||:|..::.:..|:. |:.:||.::.|   .|:|.|:|||.::  .|.|.||:.||..|
Mouse    69 LQYLEQQALEVKERDDLVPYT-GEKKGKPFIQP---KREIPAQEQITLE--PELEEALSHATDAE 127

  Fly   218 IIDLAAILGFHSMMNQDQYHASLLNKGQPVGL-GWDGITKSTQQKLFPMDPPNNTDVEESIKRVK 281
            :.|:|||||.:::|:..||:.::.: |:.... |...:.:..:.|..|.:|||.|::||.:|||:
Mouse   128 MCDIAAILGMYTLMSNKQYYDAICS-GEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEMLKRVR 191

  Fly   282 DDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRV 346
            .:|.:|.::|||||::|....|..|..|:..|.::...||......|..|..:|..:.::::|:.
Mouse   192 SNDKELEEVNLNNIQDIPIPVLSDLCEAMKTNTYVRSFSLVATKSGDPIANAVADMLRENRSLQS 256

  Fly   347 LNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLE 411
            ||:|:||||...::.:::|:.:..|:.|.|..|||... |:.:|||:..::|:..|::|.|.|..
Mouse   257 LNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWP-GDAVEMEMATVLEQCPSIVRFGYHFT 320

  Fly   412 FNDARHRVAAHLQRNIDRIFRVQK 435
            ....|.|.|..:.|| :.:.|.||
Mouse   321 QQGPRARAAHAMTRN-NELRRQQK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	54/144 (38%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	42/135 (31%)
Tmod4	NP_057921.1	Tropomodulin	4..143	CDD:367418	54/144 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..64		8/23 (35%)
		LRR_RI	<184..>286	CDD:393385	33/101 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345		7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848159
Domainoid	1	1.000	131	1.000	Domainoid score	I5112
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3508
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47963
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	1	1.000	-	-		FOG0001180
OrthoInspector	1	1.000	-	-		otm42558
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2851
SonicParanoid	1	1.000	-	-		X804
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940