DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and Lmod3

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_006237034.1	Gene:	Lmod3 / 500267	RGDID:	1564924	Length:	578	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	130/509 - (25%)
Similarity:	211/509 - (41%)	Gaps:	139/509 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 LSEYDDVDVESLLAQLSPEEITILAKEVD---PDDNFLPPDQRNSYECTKEATGPLNRKQLIEHI 156
            |||  ::|.:.:||.|||||:..|..|::   ||.: ||.......:..|..||..:.|.|::::
  Rat    14 LSE--ELDEDEILANLSPEELKELQSEMEVMAPDPH-LPVGMIQKDQTDKAPTGNFDHKSLVDYM 75

  Fly   157 -----NKQAIETPDQPEFEPFVQG--------KVRGKKWVPPPR--------------------- 187
                 :::.:|....|  ..|||.        :||.|.....|:
  Rat    76 YLQKASRRMLEDERVP--VSFVQSEENTQKQHEVREKGIASMPQFLKEKLNSEILAKKRQSNGSN 138

  Fly   188 ---------DARDIEAEEQIA-IDMGEEYEHALNDATQEEIIDLAAILGFHSMMNQDQYHASLLN 242
                     |..|.|.||... .|.|||.:....|...|:     |..|.:....|...:||:..
  Rat   139 NVQETEDDEDEEDEEDEEDDEDEDEGEEGDEDEEDGDGEQ-----ANRGKNEAKEQVHNNASICQ 198

  Fly   243 KGQPVGLGWDGITKSTQQ-------------KLFPMDPP-----------------NNTDVEESI 277
            :.....:.....|::.::             |:..:||.                 |.||::.|:
  Rat   199 QPATRAMEEQKATRAMEEQKDTAETKGKGAKKIAKLDPKKLALDTSFLKVSARPSGNQTDLDGSL 263

  Fly   278 KRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSK 342
            :||:.:|..:.:||||||:||..|.|.....|:.:|:|::..||.|||..:..|..||..:.:::
  Rat   264 RRVRQNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKSFSLANVGADESVAFALANMLRENR 328

  Fly   343 TLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLG 407
            ::..||:|:|||:...||.:::.|....|:.|.|..|||. :||:..||||:.|::.|::||::|
  Rat   329 SITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRH-MLGHHAEMEISRLLKANNTLLKMG 392

  Fly   408 LHLEFNDARHRVAAHLQRNIDRIFRVQKLKPNLPKLILPGNMEIERDLVA------------YNR 460
            .|.|....|..|...|.||.|:  |.||.:....:    ..::.:|.|:|            :.|
  Rat   393 YHFELPGPRMVVTNLLTRNQDK--RRQKRQEEQQQ----QQLKEQRKLIAMLENGLGLPPGMWER 451

  Fly   461 SATPSPSP------------------------------SPQPPVDYEVEEDPDN 484
            ...|.|.|                              .||||   :.:.|||:
  Rat   452 LGGPMPDPRMQEFFQPSPGRSLAAQEVPFGARKEMIKNPPQPP---QYKTDPDS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	44/184 (24%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	51/135 (38%)
Lmod3	XP_006237034.1	Tropomodulin	16..125	CDD:281268	29/113 (26%)
Lmod3	XP_006237034.1	LRR_RI	<267..>361	CDD:238064	32/93 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810