Protein Alignment tmod and LMOD2

DIOPT Version :9

• Sequence 1: NP_001247372.1
• Gene: tmod / 43633
• FlyBaseID: FBgn0082582
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_997046.1
• Gene: LMOD2 / 442721
• HGNCID: 6648
• Length: 547
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 128/485 - (26%)
• Similarity: 213/485 - (43%)
• Gaps: 93/485 - (19%)

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITILAKE---VDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            |.:.||:|:.:|.:.|||.||.||:..|.:|   ::||.| ||...|......|..||..:|:.|
Human     6 YRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRN-LPVGLRQKSLTEKTPTGTFSREAL 69

  Fly   153 IEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMG----------EEYE 207
            :.:..|::.:..::......  |||...|          .|:||::.....          ||.|
Human    70 MAYWEKESQKLLEKERLGEC--GKVAEDK----------EESEEELIFTESNSEVSEEVYTEEEE 122

  Fly   208 HALNDATQEEIID-----LAAILGFHSMMNQDQYHAS----LLNKGQPVGL----GWDGITKSTQ 259
            ....:..:||..|     :....|.:..:|.|..::.    .:.|.|...:    |.:|....:.
Human   123 EESQEEEEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESP 187

  Fly   260 QKLFPMDPPNNTDVEESIKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNV 324
            ..:.|...|  |.:|:::.::|.:|....::|||||:||:.:.|.:...||..|..::..||.|.
Human   188 AAIHPCGNP--TVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANT 250

  Fly   325 GLTDKTALLLAAAIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKI 389
            ...|..|:.:|..::.::.:..:|||:|||:...|:.:::||.....:.|.|..|||. ::|:::
Human   251 HADDSAAMAIAEMLKVNEHITNVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRH-IMGSQV 314

  Fly   390 EMEITDLVEKNSSLLRLGLHLEFNDARHRVAAHLQRNID--RIFRVQKLK--------PNL---- 440
            ||||..|:::|::|||||.|.|....|..:.:.|.||:|  |..|:|:.|        |||
Human   315 EMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKV 379

  Fly   441 ---------------------PKLILPGNMEIERDLVAYNRSATPSPSPSPQPPVDYEVEEDPDN 484
                                 ||  ||..::..|.. ..:..|||.|.|.|.||.....:..|
Human   380 WQRGTPSSSPYVSPRHSPWSSPK--LPKKVQTVRSR-PLSPVATPPPPPPPPPPPPPSSQRLP-- 439

  Fly   485 MVIRGGGDAFDPDVDPDNMVVPGSRSVTPN 514
                       |...|....:|..:.:|.|
Human   440 -----------PPPPPPPPPLPEKKLITRN 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	40/159 (25%)
		LRR_RI	<285..421	CDD:238064	46/135 (34%)
LMOD2	NP_997046.1	Interaction with actin 1. /evidence=ECO:0000269|PubMed:26417072	1..161		42/167 (25%)
		Interaction with tropomyosin alpha. /evidence=ECO:0000269|PubMed:25250574	1..47		17/41 (41%)
		Tropomodulin	6..>85	CDD:281268	26/79 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..162		15/80 (19%)
		Interaction with actin 2. /evidence=ECO:0000269|PubMed:26417072	162..497		86/316 (27%)
		LRR_RI	<223..>332	CDD:238064	36/109 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..533		27/123 (22%)
		Interaction with actin 3. /evidence=ECO:0000269|PubMed:26417072	521..540

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880