DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and TMOD4

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_037485.2	Gene:	TMOD4 / 29765	HGNCID:	11874	Length:	345	Species:	Homo sapiens

Alignment Length:	349	Identity:	120/349 - (34%)
Similarity:	205/349 - (58%)	Gaps:	13/349 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITIL---AKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            |.|:|.:|.|:|.:.:|..|||||:..|   .:|:||::..||...|...:..|..||||:|:.|
Human     4 YQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDREAL 68

  Fly   153 IEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEE 217
            ::::.:||:|..::.:..||. |:.:||.::.|   .|:|.|||||.::  .|.|.||..||..|
Human    69 LQYLEQQALEVKERDDLVPFT-GEKKGKPYIQP---KREIPAEEQITLE--PELEEALAHATDAE 127

  Fly   218 IIDLAAILGFHSMMNQDQYHASLLNKGQPVGL-GWDGITKSTQQKLFPMDPPNNTDVEESIKRVK 281
            :.|:||||..:::|:..||:.:|.: |:.... |...:.:..:.|..|.:|||.|::||.:|||:
Human   128 MCDIAAILDMYTLMSNKQYYDALCS-GEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEILKRVR 191

  Fly   282 DDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRV 346
            .:|.:|.::|||||::|....|.:|..|:..|.::...||......|..|..:|..:.::::|:.
Human   192 SNDKELEEVNLNNIQDIPIPMLSELCEAMKANTYVRSFSLVATRSGDPIANAVADMLRENRSLQS 256

  Fly   347 LNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLE 411
            ||:|:||||...::.:::|:.:..|:.|.|..|||... |:.:|||:..::|:..|::|.|.|..
Human   257 LNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWP-GDAVEMEMATVLEQCPSIVRFGYHFT 320

  Fly   412 FNDARHRVAAHLQRNIDRIFRVQK 435
            ....|.|.|..:.|| :.:.|.||
Human   321 QQGPRARAAQAMTRN-NELRRQQK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	55/144 (38%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	42/135 (31%)
TMOD4	NP_037485.2	Tropomodulin	4..143	CDD:397382	55/144 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..63		6/20 (30%)
		LRR_RI	<184..>286	CDD:423007	33/101 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157771
Domainoid	1	1.000	134	1.000	Domainoid score	I5012
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3507
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47963
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	1	1.000	-	-		FOG0001180
OrthoInspector	1	1.000	-	-		otm40482
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2851
SonicParanoid	1	1.000	-	-		X804
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940