DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and Lmod2

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001094434.1	Gene:	Lmod2 / 296935	RGDID:	1592092	Length:	549	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	129/498 - (25%)
Similarity:	219/498 - (43%)	Gaps:	117/498 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITILAKE---VDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            |.:.||:|:.:|.:.|||.|:.||:..|.:|   ::||.| ||...|......|..||..:|:.|
  Rat     6 YRRGLSKYESIDEDELLASLTAEELKELERELEDIEPDRN-LPVGLRQKSLTEKTPTGNFSREAL 69

  Fly   153 IEHINKQA--------------IETPDQPEFEP---FVQGKVRGKKWVPPPRDARDIEAEEQIAI 200
            :.:..|::              :...|:.|.|.   |.:......:.|....:....|.||:
  Rat    70 MAYWEKESQKLLEKERLGECGKLAEEDKEESEEELIFTESNSEVSEEVCTEEEEESTEEEEE--- 131

  Fly   201 DMGEEYEHALNDATQEEIIDLAA--ILG--FHSMMNQDQ-----YHASLLNKGQPVGL--GWDGI 254
               ||.|    |:.:||:.....  |.|  .|:.:|.|.     :.:.:.|    :.|  |..|.
  Rat   132 ---EEEE----DSEEEEVTTEVTKHINGTVSHNGVNPDNSKPKTFKSQIEN----INLTNGNSGG 185

  Fly   255 TKSTQQKLFPMDPPNN-TDVEESIKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEV 318
            |:...:....:.|..| |.:|::::::|::|....::|||||:||:.:.|.:...||.:|..::.
  Rat   186 TQRNTESPAAIHPCGNPTVIEDALEKIKNNDPDTTEVNLNNIENITTQTLSRFAEALKENTVVKT 250

  Fly   319 LSLTNVGLTDKTALLLAAAIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSA 383
            .||.|....|..|:.:|..::.::.:..:|||:|||:...|:.:::||.....:.|.|..|||.
  Rat   251 FSLANTHADDAAAIAIAEMLKVNEHITSVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRH- 314

  Fly   384 VLGNKIEMEITDLVEKNSSLLRLGLHLEFNDARHRVAAHLQRNID--RIFRVQKLK--------- 437
            ::|:::||||..|:::|::|||||.|.|....|..:.:.|.||:|  |..|:|:.|
  Rat   315 IMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRMQEQKQQEGHDGGA 379

  Fly   438 ---------------------------PNLPKLILPGNMEIERDLVAYNRSATPS----PSPSPQ 471
                                       |.:.|.:..|            ||..||    |.|.|.
  Rat   380 TLRTKVWQRGTPGSSPYASPRQSPWSSPKVSKKVHTG------------RSRPPSPVAPPPPPPP 432

  Fly   472 PPVDYEVEEDPDNMVIRGGGDAFDPDVDPDNMVVPGSRSVTPN 514
            ||:       |.:|:        .|...|....:||.:.:|.|
  Rat   433 PPL-------PPHML--------PPPPPPPAPPLPGKKLITRN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	42/165 (25%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	46/135 (34%)
Lmod2	NP_001094434.1	Interaction with actin 1. /evidence=ECO:0000250\|UniProtKB:Q6P5Q4	1..164		44/168 (26%)
		Interaction with tropomyosin alpha. /evidence=ECO:0000250\|UniProtKB:Q6P5Q4	1..47		16/41 (39%)
		Tropomyosin-binding. /evidence=ECO:0000250	1..42		13/35 (37%)
		Tropomodulin	6..>85	CDD:281268	25/79 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..166		19/84 (23%)
		Interaction with actin 2. /evidence=ECO:0000250\|UniProtKB:Q6P5Q4	165..499		85/328 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..200		4/20 (20%)
		LRR_RI	<229..>338	CDD:238064	36/109 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..455		23/123 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..534
		Interaction with actin 3. /evidence=ECO:0000250\|UniProtKB:Q6P5Q4	523..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3491
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.970