DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and Tmod4

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001099919.1	Gene:	Tmod4 / 295261	RGDID:	1308940	Length:	345	Species:	Rattus norvegicus

Alignment Length:	349	Identity:	119/349 - (34%)
Similarity:	204/349 - (58%)	Gaps:	13/349 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITIL---AKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            |.|:|.:|.|:|.:.:|..|||||:..|   .:|:||::..||...|...:..|..||||:|..|
  Rat     4 YQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDRDAL 68

  Fly   153 IEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEE 217
            ::::.:||:|..::.:..||. |:.:||.::.|   .|:|.|:|||.::  .|.|.||:.||..|
  Rat    69 LQYLEQQALEVKERDDLVPFT-GEKKGKPFIQP---KREIPAQEQITLE--PELEEALSHATDAE 127

  Fly   218 IIDLAAILGFHSMMNQDQYHASLLNKGQPVGL-GWDGITKSTQQKLFPMDPPNNTDVEESIKRVK 281
            :.|:|||||.:::|:..||:.::.: |:.... |...:.:..:.|..|.:|||.|::||.:|||:
  Rat   128 MCDIAAILGMYTLMSNKQYYDAICS-GEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEMLKRVR 191

  Fly   282 DDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRV 346
            .:|.:|.::|||||::|....|..|..|:..|.::...||......|..|..:|..:.::::|..
  Rat   192 SNDKELEEVNLNNIQDIPIPVLSDLCEAMKTNTYVRSFSLVATKSGDPIANAVADMLRENRSLLS 256

  Fly   347 LNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLE 411
            ||:|:||||...::.:::|:.:..|:.|.|..|||... |:.:|||:..::|:..|::|.|.|..
  Rat   257 LNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWP-GDAVEMEMATVLEQCPSIVRFGYHFT 320

  Fly   412 FNDARHRVAAHLQRNIDRIFRVQK 435
            ....|.|.|..:.|| :.:.|.||
  Rat   321 QQGPRARAANAMTRN-NELRRQQK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	55/144 (38%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	42/135 (31%)
Tmod4	NP_001099919.1	Tropomodulin	4..143	CDD:397382	55/144 (38%)
Tmod4	NP_001099919.1	LRR_RI	<184..>286	CDD:423007	33/101 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351737
Domainoid	1	1.000	127	1.000	Domainoid score	I5235
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3491
OMA	1	1.010	-	-		QHG47963
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	1	1.000	-	-		FOG0001180
OrthoInspector	1	1.000	-	-		otm44624
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X804
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910