Protein Alignment tmod and LMOD1

DIOPT Version :9

• Sequence 1: NP_001247372.1
• Gene: tmod / 43633
• FlyBaseID: FBgn0082582
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_036266.2
• Gene: LMOD1 / 25802
• HGNCID: 6647
• Length: 600
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 141/553 - (25%)
• Similarity: 223/553 - (40%)
• Gaps: 163/553 - (29%)

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITILAKE---VDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            |.:.:||  |.|::|||..|||||:..|.||   ||||.: :|...|...:..|::||..||:.:
Human     7 YRRQVSE--DPDIDSLLETLSPEEMEELEKELDVVDPDGS-VPVGLRQRNQTEKQSTGVYNREAM 68

  Fly   153 IEHINKQA---------------IETPDQPEFEPFVQGKVRG----KKWVPPPRDA--------- 189
            :....|:.               :||....:     .|:.||    ||.:.|.||:
Human    69 LNFCEKETKKLMQREMSMDESKQVETKTDAK-----NGEERGRDASKKALGPRRDSDLGKEPKRG 128

  Fly   190 ---------RDIEA---------EEQI-----------AID--------MGEEYEHAL------- 210
                     || ||         ||:|           |:|        .|||...|.
Human   129 GLKKSFSRDRD-EAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKK 192

  Fly   211 -----------NDATQEEIIDLA-------------------------AILGFHSMMNQDQ---- 235
                       .|..:||:.::|                         ...|...|..:|:
Human   193 GSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKR 257

  Fly   236 --------YHASLLNKGQPV---GLGWDGITKSTQQKLFPMDPPNNTD-------------VEES 276
                    .....:.|.:|:   ....|..|| |.:|..|..|...::             .:|.
Human   258 GTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTK-TPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEP 321

  Fly   277 IKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKS 341
            ::|||::|.::.::|:||...|::|.|.:...||..|..:::.:|.|....|..|..:|..::.:
Human   322 LERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKAN 386

  Fly   342 KTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRL 406
            ||:..||:::|.|:...|:.:.:|||:.:|:.|.|..|||. :.|.|.||||..|:::|::||:|
Human   387 KTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFHNQRH-ICGGKTEMEIAKLLKENTTLLKL 450

  Fly   407 GLHLEFNDARHRVAAHLQRNIDRIFRVQKLKPNLPKLILPGN----MEIERDLVAYNRSATPSPS 467
            |.|.|....|..|...|.||:|: .|.::|:.........|.    :|:.:.......|..|||.
Human   451 GYHFELAGPRMTVTNLLSRNMDK-QRQKRLQEQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQ 514

  Fly   468 PSPQPPVDYEVEEDPDNMVIRGGGDAFDPDVDP 500
            |||:|        .|.|...:||..|..|...|
Human   515 PSPKP--------SPKNSPKKGGAPAAPPPPPP 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	57/252 (23%)
		LRR_RI	<285..421	CDD:238064	46/135 (34%)
LMOD1	NP_036266.2	Tropomodulin	7..>83	CDD:281268	28/78 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..61		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..324		40/250 (16%)
		TEBP_beta	<159..298	CDD:254188	21/139 (15%)
		8 X approximate tandem repeats	165..293		19/128 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	472..573		20/77 (26%)
		5 X 4 AA approximate tandem repeats	508..527		10/26 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810