DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and Tmod1

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_068683.1	Gene:	Tmod1 / 21916	MGIID:	98775	Length:	359	Species:	Mus musculus

Alignment Length:	366	Identity:	136/366 - (37%)
Similarity:	214/366 - (58%)	Gaps:	28/366 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YGKDLSEYDDVDVESLLAQLSPEEITILAK---EVDPDDNFLPPDQRNSYECTKEATGPLNRKQL 152
            |.::|.:|.|:|.:.:|..|:.||:..|..   |:|||:..||...|...:.||..|||..|::|
Mouse     3 YRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREEL 67

  Fly   153 IEHINKQAIETPDQPEFEPFVQGKVRGKKWVP--PPRDARDIEAEEQIAIDMGEEYEHALNDATQ 215
            ::|:.|||.|..|:.:..|:. |:.|||.|||  .|.|    ...|.:.::  .|.|.||.:|:.
Mouse    68 LDHLEKQAKEFKDREDLVPYT-GEKRGKVWVPKQKPMD----PVLESVTLE--PELEEALANASD 125

  Fly   216 EEIIDLAAILGFHSMMNQDQYH-----ASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEE 275
            .|:.|:|||||.|::|:..||:     :|::||.     |.:.:.|.||.|..|.:.||:|||||
Mouse   126 AELCDIAAILGMHTLMSNQQYYQALGSSSIVNKE-----GLNSVIKPTQYKPVPDEEPNSTDVEE 185

  Fly   276 SIKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEK 340
            :::|:|::|.:|.::|||||:||....|:....||.:|.:::..|:......|..|..||..::.
Mouse   186 TLERIKNNDPELEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAFALAEMLKV 250

  Fly   341 SKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLR 405
            :|.|:.||||:||||...|::||:||....::.|.:..|| |..||||:||||.:::|||::||:
Mouse   251 NKVLKTLNVESNFISGAGILRLVEALPHNTSLVELKIDNQ-SQPLGNKVEMEIVNMLEKNTTLLK 314

  Fly   406 LGLHLEFNDARHRVAAHLQRNIDRIFRVQKLK----PNLPK 442
            .|.|......|.|.:..:..|.| :.|.::|.    |.:||
Mouse   315 FGYHFTQQGPRLRASNAMMSNND-LVRKRRLADLTGPIIPK 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	55/146 (38%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	53/135 (39%)
Tmod1	NP_068683.1	Tropomodulin	3..143	CDD:281268	55/146 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..61		10/24 (42%)
		Tropomyosin-binding. /evidence=ECO:0000255	39..138		41/105 (39%)
		LRR_RI	<195..>289	CDD:238064	33/93 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848155
Domainoid	1	1.000	131	1.000	Domainoid score	I5112
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20701
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3508
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47963
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	1	1.000	-	-		FOG0001180
OrthoInspector	1	1.000	-	-		otm42558
orthoMCL	1	0.900	-	-		OOG6_105629
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2851
SonicParanoid	1	1.000	-	-		X804
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840