DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and tmd-2

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_872143.2	Gene:	tmd-2 / 179216	WormBaseID:	WBGene00006582	Length:	639	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	99/383 - (25%)
Similarity:	160/383 - (41%)	Gaps:	75/383 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 DATQEEIIDLAAILGFHSMMNQDQYHASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEES 276
            :|.:.||.||...:..:.:::.|:....|:...|      ..|..|..::..|.:|.|..||::.
Worm    32 EAQEREINDLLKAMHENRIVSWDEAERILMETDQ------TPIKCSLPEQTRPTEPENEVDVDQC 90

  Fly   277 IKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKS 341
            ||::.|:|..|.::||||:|......:::|..||..|||.|.:||.|:||.|....:|...||.:
Worm    91 IKKLLDNDPSLKEINLNNMKRTPVPAIKRLLEALAYNEHCERISLANMGLYDHDINVLVTVIEMN 155

  Fly   342 KTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRL 406
            :.::.:|:|||::|.....||.:|.|...::||.:|.|| ......:.|.||.|.:.||..|.::
Worm   156 QAIKKVNLETNYLSGDFFSKLFKAALVNESVEEIKAVNQ-GVSFSTQSEKEIIDAIVKNHGLTKI 219

  Fly   407 GLHLEFNDARHRVAAHLQRN--IDRIFR------------------VQKLKPNLPKLILPGNM-- 449
            .::....:.||:|.....||  :.|:.|                  |.||.|...|...|..|
Worm   220 SINFRLPEGRHKVENATLRNGELKRVKRREAAQKARLEAEELAKNPVPKLAPEPKKEPEPKKMAP 284

  Fly   450 ----EIERDLVAYNRSATPSPSPSPQ--------PP-------------VDYEVEEDPDNMVIRG 489
                .:.:.||    |..|.||.:|:        ||             ...|.|||.:
Worm   285 KIPPAVPKSLV----SPEPKPSLAPKAAPVIATAPPKSTILMKQLSFQRASRESEEDTE------ 339

  Fly   490 GGDAFDP----DVDPDNMVVPGS---RSVTPNYDDEGVYQAHTWTSASHGPSDQELHR 540
                |.|    ...|..:.:|.:   :..||::..........|........:||.|:
Worm   340 ----FVPPPAVPEPPKKLAIPKTFMKKEETPSFQKVAKRPTRQWEPKKQESLEQEEHK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	5/20 (25%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	46/135 (34%)
tmd-2	NP_872143.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D432795at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105629
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920