DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and LRRC74A

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_011534781.1	Gene:	LRRC74A / 145497	HGNCID:	23346	Length:	529	Species:	Homo sapiens

Alignment Length:	172	Identity:	45/172 - (26%)
Similarity:	76/172 - (44%)	Gaps:	25/172 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 ESIKRVKDDDSKLI-----DLNLNNIKNISDEKLEQLFAALP-----QNEHLEVLSLTNVGLTDK 329
            |||.  |.||.|..     :|.|...|         |...:|     :|.....::|.:.||..:
Human    83 ESIH--KQDDEKFFTTGQKELYLEACK---------LMGVVPVSYFIRNMEESYVNLNHHGLGPR 136

  Fly   330 TALLLAAAIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEIT 394
            ....:|.|:..:..:..|.:|.|.|....::.||:.|.:.:.::|...||....:.|.:|   |:
Human   137 GTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI---IS 198

  Fly   395 DLVEKNSSLLRLGLHLEFNDARHRVAAHLQRNIDRIFRVQKL 436
            |..|:|||.: ..|.|..||.:...||.|.:.:...::::||
Human   199 DFFERNSSSI-WSLELSGNDFKEDSAALLCQALSTNYQIKKL 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	34/145 (23%)
LRRC74A	XP_011534781.1	LRR_RI	128..384	CDD:330982	32/116 (28%)
		leucine-rich repeat	152..174	CDD:275380	6/21 (29%)
		leucine-rich repeat	179..207	CDD:275380	10/30 (33%)
		leucine-rich repeat	208..235	CDD:275380	7/27 (26%)
		leucine-rich repeat	236..259	CDD:275380	2/4 (50%)
		leucine-rich repeat	264..291	CDD:275380
		leucine-rich repeat	292..319	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910