DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and lrrc45

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_012827024.2	Gene:	lrrc45 / 100379987	XenbaseID:	XB-GENE-5885628	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	485	Identity:	96/485 - (19%)
Similarity:	183/485 - (37%)	Gaps:	149/485 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SKTSVVTEHTEEVIPGETEKMVT--ETIDEDGDVVEETTEVTRKTVKRTMKITET--SATTKTTT 83
            ::..::|:..:.:...:..:.:.  ||||:..   ||...:.|..|.:..|:..|  ..|:...:
Frog   335 NQQQILTKEVQNLKQDKNRQFINMMETIDKQR---EEMNSINRNAVLQAGKLRGTLEERTSVVNS 396

  Fly    84 LTTPAKLYGKD--LSEYDDVDVESLLAQLSPEEITILAK---------------EVDPDDNFLPP 131
            ||...:|...|  ||...:.|:..||.|:..::.:::.|               |.....:....
Frog   397 LTAKLQLMEADLALSHQKEQDLGDLLRQVKQQDSSMMEKHAKELMKAKEEFREHEAKRRRDLAAA 461

  Fly   132 DQRNSYECTKEATGPLNRK-----QLIEHINKQAIETPDQPEF------EPFVQGKVRGKKWVPP 185
            :::|.:..:|  ...|.||     .|:..:.::...|..:.:.      |.|...|.|.:::
Frog   462 NEKNLHYRSK--IDELERKCQTQQDLVFELKQELTNTTAELKLRAVQAEERFEAEKKRFRQF--- 521

  Fly   186 PRD-------------ARDIEAEEQI---------AIDMGEEYEHA------LNDATQEEIIDLA 222
             ||             |:.:|..|::         |..:|.|.|.:      .|..||.| .:|.
Frog   522 -RDNSTTLHQKEVDHMAKHLEDAERVTQERVQRLEATKLGLEEELSRLKIMLANQHTQAE-EELQ 584

  Fly   223 AILGFHSMMNQDQYHASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEES--IKRVKDDDS 285
            .:..|..:  ::|.|:::|:         |.:...||.:    |...|..::::  |..::..::
Frog   585 KVRSFVQL--EEQQHSAVLH---------DKLRTLTQSR----DQAQNQVLQQNQMIGELQTKNN 634

  Fly   286 KL---IDLNLNNIKNISDE---KLEQLFAAL--------PQNEHLEVLSLTNVGLTDKTALLLAA 336
            :|   |::....|..|..|   |.|:..:||        .|..|||....|..||.:|     .:
Frog   635 QLSLEIEVLKRRIDGIQQELATKEEEKLSALTKVRVEFHEQIGHLEAQLATQEGLREK-----IS 694

  Fly   337 AIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVE--- 398
            |:|:.:.::                                |:|...:|.:| |.||:.|:|
Frog   695 ALERQQKVQ--------------------------------SHQHREILLDK-ESEISTLMEKLR 726

  Fly   399 -KNSSLLRLGLHLEFNDARHRVAAHLQRNI 427
             |::.:||:.     .:..|| |..||..|
Frog   727 LKDAEILRIR-----EEEAHR-ACLLQNAI 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	35/197 (18%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	33/153 (22%)
lrrc45	XP_012827024.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910