DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and Lrrc74b

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_003751144.4	Gene:	Lrrc74b / 100361946	RGDID:	2319134	Length:	397	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	77/387 - (19%)
Similarity:	127/387 - (32%)	Gaps:	106/387 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KMVTETIDEDGDVV-----EETTEVTRKTVKRTMKITETSATTKTTTLTTPAKLYGKDLSEYDDV 101
            |.|.:..|::|:..     .||.|..:.....:....||..|..... ...|.||.:.......|
  Rat     6 KEVQKNEDQEGEAAATGPQAETLEAKKSWTANSHSALETEGTHGLGE-RVMADLYLESCRANSVV 69

  Fly   102 DVESLLAQLSPEEITILAKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQLIEHINKQAIETPDQ 166
            .|..||.|.|..|:.:..:.:.|         :.........|..|..|:|
  Rat    70 PVSRLLRQGSASELNLQHRGLGP---------QGIRALASTLTSNLYIKRL-------------- 111

  Fly   167 PEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEEIIDLAAILGFHSMM 231
                                 |.||.|                |..|..|.:.|   :|..:|::
  Rat   112 ---------------------DLRDNE----------------LGGAGAEALAD---VLRKNSVI 136

  Fly   232 NQDQYHASLLNKGQPVGLGWDGITKS-----TQQKLFPMDPPNNTDVEESIKR-----VKDDDSK 286
            :...     |::.|....|...|..:     |.||   |....|...|::.:.     ::....|
  Rat   137 SDVD-----LSENQIGAAGLQAICTALTLNPTVQK---MQLQGNRLEEKAAQHLAALLLRHTGLK 193

  Fly   287 LIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRVLNVET 351
            .:||:.|.:.:::.|.|.   .|:.:|..|..|:|:...|....|:..|..:|.:..|:||::..
  Rat   194 SLDLSYNQLNDLAGETLG---PAVAENTGLTELNLSWNHLRGLGAIAFARGLEANIFLKVLDISH 255

  Fly   352 NFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLEFN 413
            |.........:.:||...:.:||....|.|.:                .|..|:|||.|:.|
  Rat   256 NGFGDSGACAVGEALRVNNVLEELNMRNNRIS----------------TSGALKLGLGLQVN 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	23/141 (16%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	32/129 (25%)
Lrrc74b	XP_003751144.4	LRR_RI	58..359	CDD:423007	66/334 (20%)
		leucine-rich repeat	82..105	CDD:275380	3/31 (10%)
		leucine-rich repeat	106..129	CDD:275380	11/76 (14%)
		leucine-rich repeat	130..163	CDD:275380	6/37 (16%)
		leucine-rich repeat	164..187	CDD:275380	5/25 (20%)
		leucine-rich repeat	192..219	CDD:275380	8/29 (28%)
		leucine-rich repeat	220..244	CDD:275380	6/23 (26%)
		leucine-rich repeat	248..275	CDD:275380	6/26 (23%)
		leucine-rich repeat	276..303	CDD:275380	11/42 (26%)
		leucine-rich repeat	304..328	CDD:275380
		leucine-rich repeat	334..362	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910