DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and tmod1

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_005159867.1	Gene:	tmod1 / 100149766	ZFINID:	ZDB-GENE-090312-131	Length:	378	Species:	Danio rerio

Alignment Length:	345	Identity:	132/345 - (38%)
Similarity:	198/345 - (57%)	Gaps:	11/345 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KDLSEYDDVDVESLLAQLSPEEITIL---AKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQLIE 154
            |::.:|.|||.:.||.:||.||:..|   .:|:|||:..||...|...:..|..||...|..|:.
Zfish     4 KEMEKYRDVDEDELLQKLSEEELRRLEDELEELDPDNALLPAGYRQRDQTKKAPTGTFQRDNLLA 68

  Fly   155 HINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEEII 219
            |:.|||.|.||:.:..|:. |:.|||.|||..:....:..:    :.:..|.|.||:.||..|:.
Zfish    69 HLEKQAKEHPDRDDLVPYT-GEKRGKPWVPKSKVVDPLLED----VTLEPELEEALSSATDAELC 128

  Fly   220 DLAAILGFHSMMNQDQYHASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEESIKRVKDDD 284
            |:|||||.|::|:..||:.:|.:.......|.:.:.:.||.|..|.:.||:|||||:::|||.:|
Zfish   129 DIAAILGMHTLMSNQQYYEALASSTIVNKQGLNSVIQCTQYKPVPDEEPNDTDVEETLQRVKSND 193

  Fly   285 SKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRVLNV 349
            ..|.::||||||||....|:....||..|..:|.||:......|..|..||..::.:.||:.|||
Zfish   194 PDLTEVNLNNIKNIPVPTLKAYAEALKGNSVVERLSIVGTRSNDPVAFALAEMLKVNTTLKSLNV 258

  Fly   350 ETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLEFND 414
            |:|||:...::.||:||....|::|.:..|| |..||||:||||.:::|||::||:.|.|.....
Zfish   259 ESNFITGAGVLALVEALKSNTTLQELKIDNQ-SQPLGNKVEMEIANILEKNTTLLKFGYHFTQQG 322

  Fly   415 ARHRVAAHLQRNID--RIFR 432
            .|.|.:..:..|.|  |:.|
Zfish   323 PRLRGSNAMMNNNDMARVVR 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	54/142 (38%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	55/135 (41%)
tmod1	XP_005159867.1	Tropomodulin	3..142	CDD:308723	54/142 (38%)
tmod1	XP_005159867.1	LRR_RI	<190..>313	CDD:330982	52/123 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593550
Domainoid	1	1.000	134	1.000	Domainoid score	I4956
eggNOG	1	0.900	-	-		E1_KOG3735
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20701
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3510
OMA	1	1.010	-	-		QHG47963
OrthoDB	1	1.010	-	-		D1025132at2759
OrthoFinder	1	1.000	-	-		FOG0001180
OrthoInspector	1	1.000	-	-		otm25480
orthoMCL	1	0.900	-	-		OOG6_105629
Panther	1	1.100	-	-	O	PTHR10901
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2851
SonicParanoid	1	1.000	-	-		X804
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840