DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tmod and lrrc34

DIOPT Version :9

Sequence 1:	NP_001247372.1	Gene:	tmod / 43633	FlyBaseID:	FBgn0082582	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001106443.1	Gene:	lrrc34 / 100127617	XenbaseID:	XB-GENE-998066	Length:	409	Species:	Xenopus tropicalis

Alignment Length:	300	Identity:	60/300 - (20%)
Similarity:	117/300 - (39%)	Gaps:	71/300 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 MNQDQYHASLLN-KGQPVG-LGWDGITKSTQQKLFPMDPP---NNTDVEESIKRVKDDDSKL--- 287
            :|..|.:..:.: :.||:. ...:.::::.:|:|:.....   ||..|:  ::||.|:|..:
Frog     3 VNMQQLYTEVCSEQNQPINPFIAEILSQTEEQELYASTLKLCGNNRLVQ--VQRVSDEDFLVLAQ 65

  Fly   288 ----------IDLNLNNI-------------------------KNISDEKLEQLFAALPQNEHLE 317
                      :||..|.:                         ..|..:..|.:..||.:|..|.
Frog    66 VLSKNSFITNLDLRYNRVTDNGAAHIATFLQNNSSVLCLNIMGNEIGTDGSEHITKALHRNTTLL 130

  Fly   318 VLSLTNVGLTDKTALLLAAAIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRS 382
            .|.:|...:.:|..:|.|:.::.:.||..|::....:....::.|...||:..|::....:....
Frog   131 SLRMTGDKIGNKGGMLFASMLQINSTLEELDLGDCDLGIQSLIALATVLLQNKTLKSLNLNRPIF 195

  Fly   383 AVLGNKIEMEITDLVEKNSSL--LRLGLH--LEFN-----DARH--RVAAHLQRNIDRIFR---- 432
            .|:.....:.:::::..||:|  |.|..|  .:|.     ||.|  ....:|..:.::|.|
Frog   196 YVMQEDTTVHLSEMLRVNSTLQELHLSKHEITDFGVQRLCDALHENHTLKYLNLSCNKITRDGVK 260

  Fly   433 ----VQKLKPNLPKLILPGN-ME------IERDLVAYNRS 461
                |.|:...|..|.|..| ||      :...:..||||
Frog   261 YLAEVLKINKTLEILDLASNRMEDDGALYLAEAIYLYNRS 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tmod	NP_001247372.1	Tropomodulin	91..233	CDD:281268	0/1 (0%)
tmod	NP_001247372.1	LRR_RI	<285..421	CDD:238064	32/184 (17%)
lrrc34	NP_001106443.1	LRR_RI	64..342	CDD:393385	46/236 (19%)
		leucine-rich repeat	157..184	CDD:275381	5/26 (19%)
		leucine-rich repeat	185..215	CDD:275381	2/29 (7%)
		leucine-rich repeat	216..240	CDD:275381	7/23 (30%)
		leucine-rich repeat	244..271	CDD:275381	5/26 (19%)
		leucine-rich repeat	272..300	CDD:275381	8/27 (30%)
		leucine-rich repeat	329..352	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910