Protein Alignment ABCC1 and Mrp4

DIOPT Version :10

• Sequence 1: XP_047290087.1
• Gene: ABCC1 / 4363
• HGNCID: 51
• Length: 1584
• Species: Homo sapiens
• Sequence 2: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Alignment Length: 1381
• Identity: 493/1381 - (35%)
• Similarity: 756/1381 - (54%)
• Gaps: 161/1381 - (11%)

Human   262 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 326
            |...:|.||.:.|.:...::.:|.::.||..||:...||..|:.:...|...|.::.||
  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK------ 71

Human   327 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY-FLMSFFFKAIHDL 390
                                ||              .|.|.:.|.|.||.: |:...|..|...|
  Fly    72 --------------------NE--------------TPRLGRALTKVFGFHLFITGVFLLAQEFL 102

Human   391 MMFSGPQILKLLIKFV--ND---TKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKT 450
            ...:.|..|..::.:.  ||   :||..|........:| :.|:.    |.|.......||:::.
  Fly   103 TKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF-SVCIG----HPYMLGLLHLGMKMRI 162

Human   451 AVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNL 515
            |:...:|||||.::.:|...:|||::|||:|.|..||..:...::.:|.|||::|...||::|.:
  Fly   163 ALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEI 227

Human   516 GPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDK 580
            |.|.:.|||:|:|.:|..:.:..:|...::......|.|:::||||::||:|:|:||||..|...
  Fly   228 GISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKV 292

Human   581 VLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVT-----------IDENNILDAQT 634
            |...|..|:..:|:..|:..:             |.:||::::           :...|||:|:.
  Fly   293 VEMTRFNEMLCIKQVNYIRGI-------------LISFAMFLSRIFTSSSLIAFVLLGNILNAEK 344

Human   635 AFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKD-------- 690
            ||...|.:||||..:.: .|..||...:..||::||..|:...|.:..  ::..||:
  Fly   345 AFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVR--DKSKVKNANQKAESP 407

Human   691 ------GGG--TNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 746
                  |.|  .|.|........| :.|..|||..|...:....||||:|.||.|||||:.|:|.
  Fly   408 NGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILG 472

Human   747 EMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDR 811
            |:....|.:.|.||.:|..|:.|:...::|:|||||...::..||:|::.|||..|.|:||.||:
  Fly   473 ELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDK 537

Human   812 TEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 876
            |.:||:|.:||||||.|:|||||||..|||||.||||||||.|||:|:|:..:  :|.|:::..|
  Fly   538 TIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVI 600

Human   877 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE-NGVTGVS 940
            ||||.:.:|.|.|:|::|..|:||.||:|..:......||:.|     |...:|||: :.:.|..
  Fly   601 LVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLL-----TAPNKDAEDLDEIDGAG 660

Human   941 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADK 1005
            |.|.:...:.:           |.|:.|.:|..|   :|:::.|:....||:..:|....|:..:
  Fly   661 GDGLDLLNVPS-----------LSRRGSKNSKPS---TRNNSFTSLSSMAESMAQEASLQMQETR 711

Human  1006 AQTGQVKLSVYWDYM-KAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR- 1068
            .: |::.|.:|.:|: .....|:.|..:||.:...:...|::|:||.|.|..:...|..:|..:
  Fly   712 VE-GKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQD 775

Human  1069 LSVYGALGISQGIAVFG-------YSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 1126
            :..:.||.::  :.||.       |.||:.     :|..||..:...|.|:.|.||...|||.::
  Fly   776 MYYFAALNVA--VVVFTIVRTMLFYKMAMR-----SSTQLHNAMYQGITRAAMYFFNTNPSGRIL 833

Human  1127 NRFSKELDTVDSMIP----EVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYV 1187
            |||||:|..:|.::|    :|:::|:    .::|..:||.:..|...|:...|.:|:::::.||:
  Fly   834 NRFSKDLGQLDEVLPSVMLDVVQLFL----TLLGIIVVICITNPYYLILTLALAIIFYYIREFYL 894

Human  1188 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1252
            .:||.:||||:|:|||:|||.:.|:.|:..|||...|:..|.:.|...|.:...||..:..||..
  Fly   895 KTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAF 959

Human  1253 AVRLECVGNCIVLFAALFAVI------SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1311
            ...|:|       |..|:.||      .....|.|.|||:::.::.:|..:.|.:|.|:|:|..:
  Fly   960 GYYLDC-------FCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTM 1017

Human  1312 VAVERLKEYSETEKEAPWQIQETAPPS-SWPQVGRVEFRNYCLRYRED--LDFVLRHINVTINGG 1373
            .||||:.||.|.|.|..:..:|...|| |||:.|.:...:.||||..|  ..:||:.:|..|...
  Fly  1018 TAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPC 1082

Human  1374 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLR 1438
            ||||||||||||||||...|||::.: ||.|.||..:.|.:||.|||.||:||||:|||||||:|
  Fly  1083 EKVGIVGRTGAGKSSLINALFRLSYN-EGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMR 1146

Human  1439 MNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKI 1503
            .|||||.:|:|.::|.:||...||..:|.||:.|..:.:|||.|.|||||||||||||:||:.::
  Fly  1147 YNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRV 1211

Human  1504 LVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1568
            ||:|||||.||.:||.|||:|||::|.||||||||||||||||..||:|:|.|.:.|:|:|.:||
  Fly  1212 LVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELL 1276

Human  1569 --QQRGLFYSMAKDAG 1582
              .:..:|:.|..:.|
  Fly  1277 TSSESKIFHGMVMETG 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC1	XP_047290087.1	MRP_assoc_pro	70..1583	CDD:188098	493/1381 (36%)
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	492/1379 (36%)