Protein Alignment ABCC1 and CG9270

DIOPT Version :10

• Sequence 1: XP_047290087.1
• Gene: ABCC1 / 4363
• HGNCID: 51
• Length: 1584
• Species: Homo sapiens
• Sequence 2: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Alignment Length: 1353
• Identity: 483/1353 - (35%)
• Similarity: 734/1353 - (54%)
• Gaps: 124/1353 - (9%)

Human   262 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 326
            |..||...|.:.|.:...::.:|.::.||.:||::..||..:|.:.......|:.|
  Fly    10 PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSE--------- 65

Human   327 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDL- 390
              |.|..|                      ||:||  ||:.:|:.|.||....:|.....:.:|
  Fly    66 --VRSCGD----------------------SPKKE--PSIIRVILKVFGWQLFLSGIVVGVLELG 104

Human   391 MMFSGPQILKLLI-KFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIG 454
            ...:.|.||..|| :|..:..........|.:.|.::.....|:.|..........|:::.||..
  Fly   105 TRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVST 169

Human   455 AVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSV 519
            |:|||||.::.:|...:|.|::|||:|.|..||.....:.:.:|..||:::::.|.|:..:|.:.
  Fly   170 AIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVAS 234

Human   520 LAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 584
            |.|:.:::|.:|:...::..|...:.......|.|:::||||::||:|:|:|.||..|...:..:
  Fly   235 LYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERL 299

Human   585 RQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVT----IDENNILDAQTAFVSLALFNIL 645
            |:.|:..::|..|:.  ||.    ..|.:.|...|::|:    :.....|.|:.||...|.:|||
  Fly   300 RRSEMSSIRKVNYIR--GTL----LSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNIL 358

Human   646 RFPL-NILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSI-----TVRNATF 704
            |..: ...|..:|...:..|:|:|::.|:...|.|...::      ||.||.:     .|:..:|
  Fly   359 RRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEALYLK------GGQTNKLFEGEPLVKLQSF 417

Human   705 --TWARSD-PPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQ 766
              .|.... .|.|..|..|:....||||:|.||.|||||:.|:|.|:....|.:.::|.::|..|
  Fly   418 QARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQ 482

Human   767 QAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSL 831
            :.|:.|.|:|:|||||..:::..||:||:.|||..|.|:| .||||.:||:|.:|||||:.|:||
  Fly   483 EPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISL 546

Human   832 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 896
            |||||..||.||.||||||||.|||:|:||..:  :|.|::|..|||||.:.:|...|:|::|..
  Fly   547 ARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDK 609

Human   897 GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 961
            ||||.:|:|:|:|.....|.:.|.|.|....:.:.|:....|.|...|.....::.
  Fly   610 GKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSS--------- 665

Human   962 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKA-IGL 1025
                ::|..|..|.|.|.......|.|.|:..:.:            |::.|.:|..|..| .|.
  Fly   666 ----RVSRVSVTSVDSSTESILDNERQPAQESRSQ------------GKIGLGIYGKYFSAGSGW 714

Human  1026 FISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFG----- 1085
            .:..|..|..:...:.|...:|:||.|..:   |.:...|    .:|...||:..:.:|.
  Fly   715 LMVILVAFFCLGTQILASGGDYFLSYWVKN---NDSSSST----DIYIFSGINAALVIFALLRTL 772

Human  1086 --YSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV----I 1144
              :|||:.     :|..||..:...:.|:.:.||...|||.::|||:.:|..||.::|.|    |
  Fly   773 LFFSMAMH-----SSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCI 832

Human  1145 KMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFN 1209
            ::|: ::..:||   |:.:..|...|....:.|.:.|::.||:::||.|||||:::|||:||||:
  Fly   833 QIFL-TISGIIG---VLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFS 893

Human  1210 ETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVIS 1274
            .||.|:|.|||.|.|:....:.|...|.:...||..:..||.....|:......|:...|.:..:
  Fly   894 ATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFN 958

Human  1275 RHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI-QETAPPS 1338
            ....:.|.:||.::.::.:|..:.|.:|.|:|:|.::.:|||:.||...|.|..::. .:..||.
  Fly   959 PPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPM 1023

Human  1339 SWPQVGRVEFRNYCLRYRED--LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1401
            :|||.|.:......|||..|  .|.||:.:|..|...||:|||||||||||||...|||::.: |
  Fly  1024 NWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYN-E 1087

Human  1402 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVS 1466
            |.::||..:|..|||||||.||:||||:||||||:||.|||||.||:||::|.:||..||||.||
  Fly  1088 GSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVS 1152

Human  1467 ALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED 1531
            .||:.|:...||||.|.|||||||||||||:||:.:|||:|||||.||.:||.|||||||.:|.|
  Fly  1153 ELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRD 1217

Human  1532 CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ--RGLFYSMAKDAG 1582
            |||||||||||||:|..||:|||.|.:.|:|:|.:||.|  ..:||.|....|
  Fly  1218 CTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC1	XP_047290087.1	MRP_assoc_pro	70..1583	CDD:188098	483/1353 (36%)
CG9270	NP_995741.2	PLN03130	10..1289	CDD:215595	483/1353 (36%)