Protein Alignment CG9698 and P4HA2

DIOPT Version :10

• Sequence 1: NP_651806.2
• Gene: CG9698 / 43629
• FlyBaseID: FBgn0039784
• Length: 547
• Species: Drosophila melanogaster
• Sequence 2: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 173/540 - (32%)
• Similarity: 264/540 - (48%)
• Gaps: 36/540 - (6%)

  Fly     7 SVLFLLFHQAIPSVSGVEFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENER 71
            |.|.:.:...:..|. .|||:||..||.:...|:::|..:::::...:.||..:|:...:.|...
Human     6 SALLMAWFGVLSCVQ-AEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALT 69

  Fly    72 NEAREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGEKPLTRLRKFRNRETMPDKKELEGA 136
            :::......|...|:|.|.|.|||..||..:|:|:...:....:..|..  .|:..|..::..||
Human    70 SKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSV--QRQFFPTDEDEIGA 132

  Fly   137 IDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIARLALRD---QHPRLAHSWLIEAND 198
            ...|:|||..|||....::||.|.|..|...|:.:.|..:.|.|..:   .|..|   |:.:...
Human   133 AKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVL---WMEQVLK 194

  Fly   199 RLTGGEKEEQLKPQILALLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKN---YETFLNALSE 260
            :|..||:....|.|:|..|..|..:|.|.....:..:.|:.:..:.|....|   :|..|....|
Human   195 QLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEERE 259

  Fly   261 KALLNESKPILEHAPIPEEG---EPVG---EFQAYSLTCSGHW-RLTPKEQRHLRCGYVTETH-- 316
            |.|.|:::..|    ...||   .||.   |...|...|.|.. :|||:.|:.|.|.|    |
Human   260 KTLTNQTEAEL----ATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRY----HHG 316

  Fly   317 ---PFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIRKLTENRLMRATITSHNESV--VSNVRT 376
               |.|.|||.|.|:.:..|.:|.|:||:...||:.|:::.:.:|.|||:......|  |::.|.
Human   317 NRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRV 381

  Fly   377 SQFTFIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAGLVSS 441
            |:.:::......|::.:::|:..:|.|.:|.||..|.||||:||.|..|.|  :....:......
Human   382 SKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFD--FSRNDERDTFKH 444

  Fly   442 PEMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGACPIIAG 506
            ...|||:||.|.|:|||..||.|.||.|...:.|||..|.||:||..||.||.||:|.|||::.|
Human   445 LGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVG 509

  Fly   507 SKWVQNRWIRENDQSDRRPC 526
            .|||.|:|..|..|...|||
Human   510 CKWVSNKWFHERGQEFLRPC 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..161	CDD:462433	37/132 (28%)
		P4Hc	345..516	CDD:214780	68/172 (40%)
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	37/132 (28%)
		BamD	159..>272	CDD:443281	28/119 (24%)
		TPR	207..240		7/32 (22%)
		P4Hc	346..519	CDD:214780	68/174 (39%)