DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9698 and P4HA2

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens

Alignment Length:	540	Identity:	173/540 - (32%)
Similarity:	264/540 - (48%)	Gaps:	36/540 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SVLFLLFHQAIPSVSGVEFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENER 71
            |.|.:.:...:..|. .|||:||..||.:...|:::|..:::::...:.||..:|:...:.|...
Human     6 SALLMAWFGVLSCVQ-AEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALT 69

  Fly    72 NEAREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGEKPLTRLRKFRNRETMPDKKELEGA 136
            :::......|...|:|.|.|.|||..||..:|:|:...:....:..|..  .|:..|..::..||
Human    70 SKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSV--QRQFFPTDEDEIGA 132

  Fly   137 IDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIARLALRD---QHPRLAHSWLIEAND 198
            ...|:|||..|||....::||.|.|..|...|:.:.|..:.|.|..:   .|..|   |:.:...
Human   133 AKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVL---WMEQVLK 194

  Fly   199 RLTGGEKEEQLKPQILALLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKN---YETFLNALSE 260
            :|..||:....|.|:|..|..|..:|.|.....:..:.|:.:..:.|....|   :|..|....|
Human   195 QLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEERE 259

  Fly   261 KALLNESKPILEHAPIPEEG---EPVG---EFQAYSLTCSGHW-RLTPKEQRHLRCGYVTETH-- 316
            |.|.|:::..|    ...||   .||.   |...|...|.|.. :|||:.|:.|.|.|    |
Human   260 KTLTNQTEAEL----ATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRY----HHG 316

  Fly   317 ---PFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIRKLTENRLMRATITSHNESV--VSNVRT 376
               |.|.|||.|.|:.:..|.:|.|:||:...||:.|:::.:.:|.|||:......|  |::.|.
Human   317 NRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRV 381

  Fly   377 SQFTFIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAGLVSS 441
            |:.:::......|::.:::|:..:|.|.:|.||..|.||||:||.|..|.|  :....:......
Human   382 SKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFD--FSRNDERDTFKH 444

  Fly   442 PEMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGACPIIAG 506
            ...|||:||.|.|:|||..||.|.||.|...:.|||..|.||:||..||.||.||:|.|||::.|
Human   445 LGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVG 509

  Fly   507 SKWVQNRWIRENDQSDRRPC 526
            .|||.|:|..|..|...|||
Human   510 CKWVSNKWFHERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	36/130 (28%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	68/172 (40%)
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	36/130 (28%)
		TPR	207..240		7/32 (22%)
		P4Hc	346..519	CDD:214780	68/174 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3267
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870